Evidence map›Paper›PMID 34887927›Full record

ReviewStem cells international2021

Cloning and Embryo Splitting in Mammalians: Brief History, Methods, and Achievements.

Mohaddeseh Rahbaran, Ehsan Razeghian, Marwah Suliman Maashi, Abduladheem Turki Jalil, Gunawan Widjaja, Lakshmi Thangavelu, Mariya Yurievna Kuznetsova, Pourya Nasirmoghadas, Farid Heidari, Faroogh Marofi and 1 more

Erratum issuedAbstract readReview
In one paragraph

Review in Stem cells international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. The Multiscale Wisdom of the Body: Collective Intelligence as a Tractable Interface for Next-Generation Biomedicine.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  2. Advances in Cellular and Molecular Biology Assays: A Review of Gold Standard Methods.International journal of innovative science and research technology · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. The effects of embryo splitting onIranian journal of veterinary research · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Mohaddeseh RahbaranAnimal Biotechnology Department, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.
Ehsan RazeghianHuman Genetics Division, Medical Biotechnology Department, National Institute of Genetics Engineering and Biotechnology (NIGEB), Tehran, Iran.
Marwah Suliman MaashiStem Cells and Regenerative Medicine Unit at King Fahad Medical Research Centre, Jeddah, Saudi Arabia.
Abduladheem Turki JalilFaculty of Biology and Ecology, Yanka Kupala State University of Grodno, Grodno, Belarus.ORCID https://orcid.org/0000-0001-8403-7465
Gunawan WidjajaUniversitas Krisnadwipayana, Jakarta, Indonesia.
Lakshmi ThangaveluDepartment of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Mariya Yurievna KuznetsovaSechenov First Moscow State Medical University, Moscow, Russia.
Pourya NasirmoghadasDepartment of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Farid HeidariAnimal Biotechnology Department, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.ORCID https://orcid.org/0000-0002-1862-2233
Faroogh MarofiDepartment of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Mostafa JarahianGerman Cancer Research Center, Toxicology and Chemotherapy Unit (G401), 69120 Heidelberg, Germany.ORCID https://orcid.org/0000-0003-2464-5383

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Embryo splitting is one of the newest developed methods in reproductive biotechnology. In this method, after splitting embryos in 2-, 4-, and even 8-cell stages, every single blastomere can be developed separately, but the embryos are genetically identical. Embryo splitting, as an approach in reproductive cloning, is extensively employed in reproductive medicine studies, such as investigating human diseases, treating sterility, embryo donation, and gene therapy. In the present study, cloning in mammalians and cloning approaches are briefly reviewed. In addition, embryo splitting and the methods commonly used in embryo splitting and recent achievements in this field, as well as the applications of embryo splitting into livestock species, primate animals, and humans, are outlined. Finally, a perspective of embryo splitting is provided as the conclusion.

Identifiers

PMID34887927
PMCPMC8651392

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.