Evidence map›Paper›PMID 34887862›Full record

ArticleFrontiers in immunology2021

Sinomenine Hydrochloride Ameliorates Fish Foodborne Enteritis

Jiayuan Xie, Ming Li, Weidong Ye, Junwei Shan, Xuyang Zhao, You Duan, Yuhang Liu, Bruno Hamish Unger, Yingyin Cheng, Wanting Zhang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  9. Dietary Inclusion of Seabuckthorn (Frontiers in physiology · 2022
    Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Jiayuan XieInstitute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Ming LiInstitute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Weidong YeInstitute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Junwei ShanInstitute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Xuyang ZhaoInstitute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
You DuanInstitute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Yuhang LiuInstitute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Bruno Hamish UngerInstitute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Yingyin ChengInstitute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Wanting ZhangInstitute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Nan WuInstitute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Xiao-Qin XiaInstitute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Institute of Hydrobiology · CNChinese Academy of Sciences · CNDalian Ocean University · CNUniversity of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Foodborne intestinal inflammation is a major health and welfare issue in aquaculture. To prevent enteritis, various additives have been incorporated into the fish diet. Considering anti-inflammatory immune regulation, an effective natural compound could potentially treat or prevent intestinal inflammation. Our previous study has revealed galantamine's effect on soybean induced enteritis (SBMIE) and has highlighted the possible role of the cholinergic anti-inflammatory pathway in the fish gut. To further activate the intestinal cholinergic related anti-inflammatory function, α7nAchR signaling was considered. In this study, sinomenine, a typical agonist of α7nAChR in mammals, was tested to treat fish foodborne enteritis

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorAnimal FeedAnimalsAnimals, Genetically ModifiedAnti-Inflammatory AgentsBinding SitesCD4-Positive T-LymphocytesCytokinesDietEnteritisFish DiseasesGene Expression ProfilingGene OntologyIntestinal MucosaMicrobiotaMolecular Docking Simulationalpha7 Nicotinic Acetylcholine ReceptorAnti-Inflammatory AgentsCytokinesMorphinanssinomenineZebrafish Proteinsanti-inflammationmicrobiotaSBMIEsinomenine hydrochloridezebrafishα7nAChR

Identifiers

PMID34887862
PMCPMC8650311
OpenAlexW3217642974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.