Evidence map›Paper›PMID 34887833›Full record

ArticleFrontiers in endocrinology2021

Recurrence of Graves' Disease: What Genetics of HLA and

Daniela Vejrazkova, Josef Vcelak, Eliska Vaclavikova, Marketa Vankova, Katerina Zajickova, Jana Vrbikova, Michaela Duskova, Petra Pacesova, Zdenek Novak, Bela Bendlova

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. A Predictive Model for Graves' Disease Recurrence After Antithyroid Drug Therapy: A Retrospective Multicenter Cohort Study.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2025
    Observational
  3. Article
  4. The genetics of Graves' disease.Reviews in endocrine & metabolic disorders · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Daniela VejrazkovaDepartment of Molecular Endocrinology, Institute of Endocrinology, Prague, Czechia.
Josef VcelakDepartment of Molecular Endocrinology, Institute of Endocrinology, Prague, Czechia.
Eliska VaclavikovaDepartment of Molecular Endocrinology, Institute of Endocrinology, Prague, Czechia.
Marketa VankovaDepartment of Molecular Endocrinology, Institute of Endocrinology, Prague, Czechia.
Katerina ZajickovaDepartment of Clinical Endocrinology, Institute of Endocrinology, Prague, Czechia.
Jana VrbikovaDepartment of Clinical Endocrinology, Institute of Endocrinology, Prague, Czechia.
Michaela DuskovaDepartment of Steroids and Proteohormones, Institute of Endocrinology, Prague, Czechia.
Petra PacesovaDepartment of Clinical Endocrinology, Institute of Endocrinology, Prague, Czechia.
Zdenek NovakDepartment of Clinical Endocrinology, Institute of Endocrinology, Prague, Czechia.
Bela BendlovaDepartment of Molecular Endocrinology, Institute of Endocrinology, Prague, Czechia.
Institute of Endocrinology · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Approximately half of patients diagnosed with Graves' disease (GD) relapse within two years of thyreostatic drug withdrawal. It is then necessary to decide whether to reintroduce conservative treatment that can have serious side effects, or to choose a radical approach. Familial forms of GD indicate a significant genetic component. Our aim was to evaluate the practical benefits of HLA and Methods: In 206 patients with GD, exon 2 in the HLA genes Results: The risk HLA haplotype Conclusion: the

Indexed as

AdultAllelesFemaleGene FrequencyGenetic Predisposition to DiseaseGraves DiseaseHaplotypesHistocompatibility Antigens Class IHumansMaleProtein Tyrosine Phosphatase, Non-Receptor Type 22RecurrenceRetrospective StudiesHistocompatibility Antigens Class IProtein Tyrosine Phosphatase, Non-Receptor Type 22PTPN22 protein, humangenetic predictorsGraves’ diseaseHLA variantsPTPN22 genetreatment

Identifiers

PMID34887833
PMCPMC8650699
OpenAlexW3216618610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.