Evidence map›Paper›PMID 34887676›Full record

ArticleInternational journal of nephrology and renovascular disease2021

A Case of Acute Interstitial Nephritis After Two Doses of the BNT162b2 SARS-CoV-2 Vaccine.

Filipe S Mira, Jóni Costa Carvalho, Patrícia Amaral de Almeida, Ana Carolina Pimenta, Iolanda Alen Coutinho, Carolina Figueiredo, Luís Rodrigues, Vítor Sousa, Emanuel Ferreira, Helena Pinto and 3 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in International journal of nephrology and renovascular disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

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  13. Renal Complications Following COVID-19 Vaccination: A Narrative Literature Review.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Filipe S Mira *Nephrology Department, Coimbra University Hospital, Coimbra, Portugal.
Jóni Costa Carvalho *Allergy and Clinical Immunology Department, Coimbra University Hospital, Coimbra, Portugal.ORCID 0000-0002-0444-7745
Patrícia Amaral de AlmeidaInternal Medicine Department, Figueira da Foz Hospital, Figueira da Foz, Portugal.ORCID 0000-0002-5220-3462
Ana Carolina PimentaNephrology Department, Coimbra University Hospital, Coimbra, Portugal.ORCID 0000-0003-3992-0763
Iolanda Alen CoutinhoAllergy and Clinical Immunology Department, Coimbra University Hospital, Coimbra, Portugal.
Carolina FigueiredoNephrology Department, Coimbra University Hospital, Coimbra, Portugal.
Luís RodriguesNephrology Department, Coimbra University Hospital, Coimbra, Portugal.ORCID 0000-0003-0122-982X
Vítor SousaCoimbra University Faculty of Medicine, Coimbra, Portugal.
Emanuel FerreiraNephrology Department, Coimbra University Hospital, Coimbra, Portugal.
Helena PintoNephrology Department, Coimbra University Hospital, Coimbra, Portugal.
Luís EscadaNephrology Department, Coimbra University Hospital, Coimbra, Portugal.
Ana GalvãoNephrology Department, Coimbra University Hospital, Coimbra, Portugal.
Rui AlvesNephrology Department, Coimbra University Hospital, Coimbra, Portugal.
University of Coimbra · PTCelulose Beira Industrial (Portugal) · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe development of vaccines to prevent COVID-19 breakouts came with highly positive results but some unexpected side effects. Rare side effects have been seen with the BNT162b2 SARS-CoV 2 vaccine. CASE PRESENTATION: We present the case of a 45-year-old female patient who developed an acute kidney injury needing urgent hemodialysis one week after the second administration of the BNT162b2 SARS-CoV 2 vaccine. She developed a macular rash on her lower limbs and palms as well. A kidney biopsy was performed 10 days after vaccine inoculation, diagnosing acute interstitial nephritis and acute tubular necrosis with cellular casts. The patient was treated with three corticosteroid pulses followed by daily prednisolone. We witnessed clinical improvement 4 days after the initial corticosteroid treatment with progressive recovery of kidney function and hemodialysis withdrawal. After 2 weeks, the patient had recovered her kidney function. Immunophenotyping was performed, diagnosing a hypersensitivity to the vaccine and the polyethylene glycol excipient.

conclusionPatients may develop acute reactions to vaccines. In this case, symptoms seem to correlate significantly with its inoculation and, although this case had a favourable outcome, these side effects must be made aware for clinicians and patients.

Indexed as

acute interstitial nephritisacute kidney injuryCOVID-19 vaccineproteinuria

Identifiers

PMID34887676
PMCPMC8650829
OpenAlexW3216854364

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.