Evidence map›Paper›PMID 34887624›Full record

ArticleWorld journal of gastroenterology2021

Nucleic acid vaccines: A taboo broken and prospect for a hepatitis B virus cure.

Efthymios P Tsounis, Athanasia Mouzaki, Christos Triantos

Open access · hybridAbstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Efthymios P TsounisDivision of Gastroenterology, Department of Internal Medicine, University of Patras, Patras 26504, Greece.
Athanasia MouzakiDivision of Hematology, Department of Internal Medicine, University of Patras, Patras 26504, Greece.
Christos TriantosDivision of Gastroenterology, Department of Internal Medicine, University of Patras, Patras 26504, Greece. chtriantos@hotmail.com.
University of Patras · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although a prophylactic vaccine is available, hepatitis B virus (HBV) remains a major cause of liver-related morbidity and mortality. Current treatment options are improving clinical outcomes in chronic hepatitis B; however, true functional cure is currently the exception rather than the rule. Nucleic acid vaccines are among the emerging immunotherapies that aim to restore weakened immune function in chronically infected hosts. DNA vaccines in particular have shown promising results

Indexed as

Hepatitis BHepatitis B, ChronicVaccines, DNAHepatitis B Surface AntigensHepatitis B VaccinesHepatitis B virusHumansNucleic Acid-Based VaccinesTabooHepatitis B Surface AntigensHepatitis B VaccinesNucleic Acid-Based VaccinesVaccines, DNAChronic hepatitis BDNA vaccinesElectroporationImmunotherapyNucleic acid vaccinesTherapeutic vaccination

Identifiers

PMID34887624
PMCPMC8613654
OpenAlexW3213114958

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.