ArticleNature2021
Half of top cancer studies fail high-profile reproducibility effort.
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Leveraging tumor dynamics to discover mutations influencing progression and treatment response for precision oncology.Genome medicine · 2026Article
- Highlighting Rigor, Reproducibility, and Transparency of Research in an Academic CV.Clinical and translational science · 2026Article
- Integration of RNA Editing into Multiomics Machine Learning Models for Predicting Drug Responses in Breast Cancer Patients.Biomedicines · 2026Article
- Integration of RNA Editing with Multiomics Data Improves Machine Learning Models for Predicting Drug Responses in Breast Cancer Patients.Research square · 2024Article
- Assessing and mitigating batch effects in large-scale omics studies.Genome biology · 2024Review
- Elements of successful NIH grant applications.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Correcting batch effects in large-scale multiomics studies using a reference-material-based ratio method.Genome biology · 2023Article
- Assessing the publishing priorities and preferences among STEM researchers at a large R1 institution.Heliyon · 2023Article
- Disclosing quantitative RT-PCR raw data during manuscript submission: a call for action.Molecular oncology · 2023Article
- From the Catastrophic Objective Irreproducibility of Cancer Research and Unavoidable Failures of Molecular Targeted Therapies to the Sparkling Hope of Supramolecular Targeted Strategies.International journal of molecular sciences · 2023Review
- Identifying barriers and enablers to rigorous conduct and reporting of preclinical laboratory studies.PLoS biology · 2023Article
- Review
- An Artificial Intelligence-Based Tool for Data Analysis and Prognosis in Cancer Patients: Results from the Clarify Study.Cancers · 2022Article
- Stem Cell Theory of Cancer: Implications for Translational Research from Bedside to Bench.Cancers · 2022Article
- Role of Environment and Experimenter in Reproducibility of Behavioral Studies With Laboratory Mice.Frontiers in behavioral neuroscience · 2022Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
34887584What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.