Trial reportNature human behaviour2022
A randomized trial of online single-session interventions for adolescent depression during COVID-19.
Trial report in Nature human behaviour, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 124 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparing Two Online Single-Session Interventions for Adolescent Depression: Outcomes of a Randomized Trial
Project Relate: Romantic Relationship Competence Single-Session Intervention Trial
How Long Should a Behavioral Activation Single-session Intervention be? A Four-armed Trial Comparing Effectiveness by Intervention Duration
Factorial Trial Designed to Identify Active Elements of a Self-administered Digital Single-session Intervention Targeting Depressive Symptoms.
Project SOLVE and Rangatahi in Aotearoa: Evaluating a Digital Single-Session Intervention for Adolescent Mental Health in New Zealand Through a School-based Randomised Controlled Trial
Who cites it
124 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Self-administered single-session interventions for mental health in young people: A systematic review and meta-analysis.Journal of child psychology and psychiatry, and allied disciplines · 2026Pooled it
- The Use of Waivers of Guardian Permission in the United States for Pediatric Digital Health Intervention Research Since 2020: Systematic Review.Journal of medical Internet research · 2026Pooled it
- Sleep Interventions and the Prevention of Pediatric Anxiety: A Systematic Review.Current psychiatry reports · 2026Pooled it
- Brief Report: Single-Session Interventions for Mental Health Challenges in Autistic People: An (Almost) Empty Systematic Review.Journal of autism and developmental disorders · 2026Pooled it
- Practice Elements Used in Child Mass Trauma Interventions: A Systematic Review.Current psychiatry reports · 2025Pooled it
- Is behavioural activation an effective treatment for depression in children and adolescents? An updated systematic review and meta-analysis.European child & adolescent psychiatry · 2024Pooled it
- Interventions to build resilience and to ameliorate negative psychosocial effects of the COVID-19 pandemic on children and adolescents: a systematic review and meta-analysis.European child & adolescent psychiatry · 2024Pooled it
- Heterogeneity of Treatment Effects in Internet- and Mobile-Based Interventions for Depression: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Effectiveness of Online and Remote Interventions for Mental Health in Children, Adolescents, and Young Adults After the Onset of the COVID-19 Pandemic: Systematic Review and Meta-Analysis.JMIR mental health · 2024Pooled it
- Interventions to improve well-being among children and youth aged 6-17 years during the COVID-19 pandemic: a systematic review.BMC medicine · 2023Pooled it
- Brief Web-Based Psychological Intervention for Depressive Symptoms Among Chinese Adolescents: Randomized Controlled Trial.JMIR mHealth and uHealth · 2026Trial
- Digital Mental Health Treatment and Symptoms of Depression and Anxiety in Breast Cancer Survivors: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Development and evaluation of a digital single-session reappraisal intervention to shift negative self-focused social media interpretations.Behaviour research and therapy · 2026Trial
- A crowdsourced megastudy of 12 digital single-session interventions for depression in US adults.Nature human behaviour · 2026Trial
- Improving Mental Health in Adolescent Girls via a Randomized Trial of an Emotion Mindset Intervention.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026Trial
- Usability testing of a digital tool to support behavioural activation for depression with young people aged 12 to 18.Frontiers in child and adolescent psychiatry · 2026Trial
- Results from a Pilot Randomized Controlled Trial of a Single-Session Growth-Mindset Intervention for Internalizing Symptoms in Autistic Youth.Journal of autism and developmental disorders · 2025Trial
- Trial
- Acceptability and Efficacy of a Web-Based, Intuitive Eating-Focused Single Session Intervention for Recurrent Binge Eating: A Randomized Controlled Trial.The International journal of eating disorders · 2025Trial
- Effects of change in dysfunctional beliefs in avatar-based cognitive therapy for depressive symptoms: a randomized parallel trial.Scientific reports · 2025Trial
64 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The COVID-19 pandemic has potentially increased the risk for adolescent depression. Even pre-pandemic, <50% of youth with depression accessed care, highlighting needs for accessible interventions. Accordingly, this randomized controlled trial (ClinicalTrials.gov: NCT04634903 ) tested online single-session interventions (SSIs) during COVID-19 in adolescents with elevated depression symptoms (N = 2,452, ages 13-16). Adolescents from all 50 US states, recruited via social media, were randomized to one of three SSIs: a behavioural activation SSI, an SSI teaching that traits are malleable and a supportive control. We tested each SSI's effects on post-intervention outcomes (hopelessness and agency) and three-month outcomes (depression, hopelessness, agency, generalized anxiety, COVID-19-related trauma and restrictive eating). Compared with the control, both active SSIs reduced three-month depressive symptoms (Cohen's d = 0.18), decreased post-intervention and three-month hopelessness (d = 0.16-0.28), increased post-intervention agency (d = 0.15-0.31) and reduced three-month restrictive eating (d = 0.12-17). Several differences between active SSIs emerged. These results confirm the utility of free-of-charge, online SSIs for high-symptom adolescents, even in the high-stress COVID-19 context.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.