SynthesisNature communications2021
Meta-analyses identify DNA methylation associated with kidney function and damage.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease.Nature communications · 2022Pooled it
- Genome-wide DNA methylation analysis revealed epigenetic mechanism underlying end-stage renal disease.Nature communications · 2026Article
- Epigenetic regulation of nephrogenesis: from Waddington's landscape to adult disease.American journal of physiology. Renal physiology · 2026Review
- Non-Invasive Measures of DNA Methylation Capture Molecular Aging in Wild Capuchin Monkeys.Molecular ecology · 2026Article
- Blood DNA methylation markers are associated with diabetic kidney disease progression in type 1 diabetes.Diabetologia · 2026Article
- State-Dependent DNA Methylation Signatures Distinguish Acute from Stable Coronary Syndromes.International journal of molecular sciences · 2026Article
- Spatial metabolomics and multiomics integration for breakthroughs in precision medicine for kidney disease.Nature reviews. Nephrology · 2026Review
- Molecular frontiers in hemodialysis: unraveling the role of membranes in gene expression, epigenetics, and inflammatory pathways.International urology and nephrology · 2025Review
- Novel approaches and applications in identifying DNA methylation markers of cardio-kidney-metabolic disease.Epigenomics · 2025Review
- DNA methylation in chronic kidney disease.BMC nephrology · 2025Review
- Mendelian randomization study revealed a gut microbiota-immune system-kidney junction axis in chronic kidney disease.Scientific reports · 2025Article
- Renal-Cardiac Crosstalk in the Pathogenesis and Progression of Heart Failure.Circulation research · 2025Review
- Emerging Biomarkers and Advanced Diagnostics in Chronic Kidney Disease: Early Detection Through Multi-Omics and AI.Diagnostics (Basel, Switzerland) · 2025Review
- Epigenetic associations with kidney disease in individuals of African ancestry with APOL1 high-risk genotypes and HIV.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- Alterations in DNA Methylation, Proteomic, and Metabolomic Profiles in African Ancestry Populations with APOL1 Risk Alleles.Journal of the American Society of Nephrology : JASN · 2025Article
- Blood-Based Epigenetic Biomarkers Associated With Incident Chronic Kidney Disease in Individuals With Type 2 Diabetes.Diabetes · 2025Article
- Role of DNA methylation transferase in urinary system diseases: From basic to clinical perspectives (Review).International journal of molecular medicine · 2025Review
- Genome-wide DNA methylation analysis identifies kidney epigenetic dysregulation in a cystinosis mouse model.Frontiers in cell and developmental biology · 2025Article
- Alteration of chromatin states perturb the transcription regulation of gene during hydronephrosis.Frontiers in genetics · 2025Article
- Longitudinal leucocyte DNA methylation changes in Mesoamerican nephropathy.Environmental epigenetics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
115 authors at 20 institutions in 14 countries.
Pascal Schlosser *Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany. pascal.schlosser@uniklinik-freiburg.de.ORCID http://orcid.org/0000-0002-8460-0462
Adrienne Tin *Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-4207-5866
Pamela R Matias-GarciaResearch Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764, Neuherberg, Bavaria, Germany.
Chris H L ThioDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0003-2623-7172
Roby JoehanesFramingham Heart Study, Framingham, Massachusetts, USA.
Hongbo LiuDepartment of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0002-0733-8616
Antoine WeihsDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-7113-0027
Zhi YuProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-4810-3474
Anselm HoppmannInstitute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.
Franziska Grundner-CulemannInstitute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0001-9649-281X
Josine L MinMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-4456-9824
Adebowale A AdeyemoCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-3105-3231
Charles AgyemangDepartment of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-3882-7295
Johan ÄrnlövDepartment of Neurobiology, Care Sciences and Society (NVS), Family Medicine and Primary Care Unit, Karolinska Institutet, Huddinge, Sweden.
Nasir A AzizPopulation Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0001-6184-458X
Andrea BaccarelliLaboratory of Environmental Precision Health, Mailman School of Public Health, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-3436-0640
Murielle BochudCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-5727-0218
Hermann BrennerGerman Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany.
Monique M B BretelerPopulation Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0002-0626-9305
Cristian CarmeliCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-1463-4587
Layal ChakerDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
John C ChambersLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Shelley A ColeTexas Biomedical Research Institute, San Antonio, USA.
Josef CoreshDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-4598-0669
Tanguy CorreCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, 39216, USA.ORCID http://orcid.org/0000-0002-9501-600X
Simon R CoxLothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.ORCID http://orcid.org/0000-0003-4036-3642
Niek de KleinDepartment of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.ORCID http://orcid.org/0000-0003-4640-9904
Graciela E DelgadoVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Arce Domingo-RellosoDepartment of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institute, Madrid, Spain.
Kai-Uwe EckardtDepartment of Nephrology and Hypertension, University of Erlangen-Nürnberg, Erlangen, Germany.ORCID http://orcid.org/0000-0003-3823-0920
Arif B EkiciInstitute of Human Genetics, Friedrich-Alexander-UniversitätErlangen-Nürnberg, 91054, Erlangen, Germany.ORCID http://orcid.org/0000-0001-6099-7066
Karlhans EndlichDepartment of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0001-6052-6061
Kathryn L EvansCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0002-7884-5877
James S FloydDepartment of Medicine, University of Washington, Seattle, WA, 98101, USA.
Myriam FornageBrown Foundation Institute of Molecular Medicine, McGovern Medical School, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0003-0677-8158
Lude FrankeDepartment of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.
Eliza FraszczykDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Xu GaoLaboratory of Environmental Precision Health, Mailman School of Public Health, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0001-6506-6084
Xīn GàoGerman Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-0108-6961
Mohsen GhanbariDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-9476-7143
Sahar GhasemiDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Christian GiegerResearch Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764, Neuherberg, Bavaria, Germany.ORCID http://orcid.org/0000-0001-6986-9554
Philip GreenlandDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Megan L GroveHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Sarah E HarrisLothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.ORCID http://orcid.org/0000-0002-4941-5106
Gibran HemaniMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-0920-1055
Peter HennemanDepartment of Clinical Genetics, Amsterdam Reproduction & Development Research Institute, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, the Netherlands.
Christian HerderInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-2050-093X
Steve HorvathDepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.ORCID http://orcid.org/0000-0002-4110-3589
Lifang HouDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Mikko A HurmeDepartment of Microbiology and Immunology, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland.ORCID http://orcid.org/0000-0002-2149-0630
Shih-Jen HwangFramingham Heart Study, Framingham, Massachusetts, USA.
Marjo-Riitta JarvelinDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48104, USA.
Silva KaselaEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Marcus E KleberVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0003-0663-7275
Wolfgang KoenigDeutsches Herzzentrum München, Technische Universität München, Munich, Germany.ORCID http://orcid.org/0000-0002-2064-9603
Jaspal S KoonerDepartment of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Southall, UK.
Holly KramerDepartments of Public Health Science and Medicine, Loyola University Chicago, Maywood, IL, USA.
Florian KronenbergInstitute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.ORCID http://orcid.org/0000-0003-2229-1120
Brigitte KühnelResearch Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764, Neuherberg, Bavaria, Germany.
Terho LehtimäkiDepartment of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID http://orcid.org/0000-0002-2555-4427
Lars LindDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Dan LiuPopulation Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Yongmei LiuDepartment of Medicine, Division of Cardiology, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Donald M Lloyd-JonesDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Kurt LohmanDepartment of Medicine, Division of Cardiology, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Stefan LorkowskiInstitute of Nutritional Sciences, Friedrich Schiller University Jena, Jena, Germany.ORCID http://orcid.org/0000-0002-9649-840X
Ake T LuDepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.ORCID http://orcid.org/0000-0002-2866-7961
Riccardo E MarioniCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Winfried MärzVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Daniel L McCartneyCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0003-3242-0360
Karlijn A C MeeksCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-3032-405X
Lili MilaniEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-5323-3102
Pashupati P MishraDepartment of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Matthias NauckDZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-6678-7964
Ana Navas-AcienDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA.
Christoph NowakDepartment of Neurobiology, Care Sciences and Society (NVS), Family Medicine and Primary Care Unit, Karolinska Institutet, Huddinge, Sweden.ORCID http://orcid.org/0000-0001-8435-3978
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764, Neuherberg, Bavaria, Germany.ORCID http://orcid.org/0000-0001-6645-0985
Holger ProkischInstitute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.ORCID http://orcid.org/0000-0003-2379-6286
Bruce M PsatyDepartment of Medicine, University of Washington, Seattle, WA, 98101, USA.ORCID http://orcid.org/0000-0002-7278-2190
Olli T RaitakariResearch centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Scott M RatliffDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48104, USA.
Alex P ReinerDepartment of Epidemiology, University of Washington, Seattle, WA, 98101, USA.ORCID http://orcid.org/0000-0002-1427-4470
Sylvia E RosasJoslin Diabetes Center, Boston, MA, USA.
Ben SchöttkerGerman Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-1217-4521
Joel SchwartzDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Sanaz SedaghatDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48104, USA.ORCID http://orcid.org/0000-0002-3575-5468
Nona SotoodehniaCardiovascular Health Research Unit, University of Washington, Seattle, WA, 98101, USA.
Hannah R StockerGerman Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-5281-2455
Silvia StringhiniCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-4387-8943
Johan SundströmDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-2247-8454
Brenton R SwensonCardiovascular Health Research Unit, University of Washington, Seattle, WA, 98101, USA.
Maria Tellez-PlazaDepartment of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institute, Madrid, Spain.ORCID http://orcid.org/0000-0002-3850-1228
Joyce B J van MeursDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Jana V van Vliet-OstaptchoukDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-7943-3153
Andrea VenemaDepartment of Clinical Genetics, Amsterdam Reproduction & Development Research Institute, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, the Netherlands.
Niek VerweijDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.
Rosie M WalkerCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0002-1060-4479
Matthias WielscherDepartment of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-4138-1383
Juliane WinkelmannInstitute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Bruce H R WolffenbuttelDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0001-9262-6921
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48104, USA.ORCID http://orcid.org/0000-0001-7388-0692
Yinan ZhengDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-2006-7320
Estonian Biobank Research Team
Genetics of DNA Methylation Consortium
Marie LohLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.ORCID http://orcid.org/0000-0003-3626-8466
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0003-1949-2298
Daniel LevyFramingham Heart Study, Framingham, Massachusetts, USA.ORCID http://orcid.org/0000-0003-1843-8724
Melanie WaldenbergerResearch Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764, Neuherberg, Bavaria, Germany.ORCID http://orcid.org/0000-0003-0583-5093
Katalin SusztakDepartment of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0002-1005-3726
Anna KöttgenInstitute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-4671-3714
Alexander TeumerDZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. ateumer@uni-greifswald.de.ORCID http://orcid.org/0000-0002-8309-094X
University Medical Center Groningen · NLGerman Cancer Research Center · DEHelmholtz Zentrum München · DEUniversity of Washington · USEdinburgh Cancer Research · GBJohns Hopkins University · USNational Institutes of Health · USNorthwestern University · USUniversitätsmedizin Greifswald · DEUniversity of Michigan · USCentre universitaire de médecine générale et santé publique, Lausanne · CHErasmus MC · NLTampere University · FIUniversity of Tartu · EEColumbia University · USDuke University · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHeidelberg University · DEImperial College Healthcare NHS Trust · GBTUM Klinikum · DE
Funding
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MMedical Research Council MC_UU_00011/5Medical Research Council MR/S019669/1NHLBI NIH HHS R01 HL105756Wellcome Trust 212945/Z/18/Z
Abstract
Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledge on regulatory mechanisms related to kidney function and disease, we conducted a blood-based epigenome-wide association study for estimated glomerular filtration rate (n = 33,605) and urinary albumin-to-creatinine ratio (n = 15,068) and detected 69 and seven CpG sites where DNA methylation was associated with the respective trait. The majority of these findings showed directionally consistent associations with the respective clinical outcomes chronic kidney disease and moderately increased albuminuria. Associations of DNA methylation with kidney function, such as CpGs at JAZF1, PELI1 and CHD2 were validated in kidney tissue. Methylation at PHRF1, LDB2, CSRNP1 and IRF5 indicated causal effects on kidney function. Enrichment analyses revealed pathways related to hemostasis and blood cell migration for estimated glomerular filtration rate, and immune cell activation and response for urinary albumin-to-creatinineratio-associated CpGs.
Indexed as
DNA MethylationAdultAgedCpG IslandsFemaleGlomerular Filtration RateHumansInterferon Regulatory FactorsKidneyKidney Function TestsLIM Domain ProteinsMaleMembrane ProteinsMiddle AgedRenal Insufficiency, ChronicTranscription FactorsInterferon Regulatory FactorsIRF5 protein, humanLDB2 protein, humanLIM Domain ProteinsMembrane ProteinsPHD and RING finger domain-containing protein 1, humanTranscription Factors
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