Evidence map›Paper›PMID 34887364›Full record

ArticleMolecules and cells2022

A Novel Pyrazolo[3,4-

Ji Ae Lee, Young-Won Kwon, Hye Ri Kim, Nari Shin, Hyo Jin Son, Chan Seong Cheong, Dong Jin Kim, Onyou Hwang

Open access · diamondAbstract read
In one paragraph

Article in Molecules and cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. NRF2 Activation by Nitrogen Heterocycles: A Review.Molecules (Basel, Switzerland) · 2023
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ji Ae LeeDepartment of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 05505, Korea.ORCID https://orcid.org/0000-0003-2194-3000
Young-Won KwonDepartment of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 05505, Korea.ORCID https://orcid.org/0000-0002-7017-1126
Hye Ri KimDepartment of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 05505, Korea.ORCID https://orcid.org/0000-0002-8903-5263
Nari ShinDepartment of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 05505, Korea.ORCID https://orcid.org/0000-0002-7017-1126
Hyo Jin SonDepartment of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 05505, Korea.ORCID https://orcid.org/0000-0002-9264-107X
Chan Seong CheongCenter for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea.ORCID https://orcid.org/0000-0002-6872-107X
Dong Jin KimCenter for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea.ORCID https://orcid.org/0000-0001-8149-8610
Onyou HwangDepartment of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 05505, Korea.ORCID https://orcid.org/0000-0003-4699-9596
Ulsan College · KRKorea Institute of Brain Science · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The anti-oxidant enzyme heme oxygenase-1 (HO-1) is known to exert anti-inflammatory effects. From a library of pyrazolo[3,4-

Indexed as

Heme Oxygenase-1Neuroprotective AgentsAnimalsAnti-Inflammatory AgentsKelch-Like ECH-Associated Protein 1LipopolysaccharidesMiceNF-E2-Related Factor 2PyrimidinesAnti-Inflammatory AgentsHeme Oxygenase-1Kelch-Like ECH-Associated Protein 1LipopolysaccharidesNeuroprotective AgentsNF-E2-Related Factor 2Pyrimidines4-heme oxygenase-1neuroinflammationParkinson’s diseasepyrazolo[3

Identifiers

PMID34887364
PMCPMC8926863
OpenAlexW4200221509

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.