Evidence map›Paper›PMID 34887356›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Endocytic proteins with prion-like domains form viscoelastic condensates that enable membrane remodeling.

Louis-Philippe Bergeron-Sandoval, Sandeep Kumar, Hossein Khadivi Heris, Catherine L A Chang, Caitlin E Cornell, Sarah L Keller, Paul François, Adam G Hendricks, Allen J Ehrlicher, Rohit V Pappu and 1 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 162 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Condensate-mediated shape transformations of cellular membranes by capillary forces.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Disulfide cross-linked redox-sensitive peptide condensates are efficient cell delivery vehicles of molecular cargo.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Biomolecular condensates-Prerequisites for anhydrobiosis?Protein science : a publication of the Protein Society · 2025
    Review
  16. Material properties of biomolecular condensates emerge from nanoscale dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Condenzymes: Biomolecular condensates with inherent catalytic activities.bioRxiv : the preprint server for biology · 2025
    Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Louis-Philippe Bergeron-SandovalDépartement de Biochimie, Université de Montréal, Montréal, QC H3C 3J7, Canada.
Sandeep KumarDépartement de Biochimie, Université de Montréal, Montréal, QC H3C 3J7, Canada.
Hossein Khadivi HerisDepartment of Bioengineering, McGill University, Montreal, QC H3A 0C3, Canada.
Catherine L A ChangDepartment of Chemistry, University of Washington, Seattle, Seattle, WA 98195-1700.
Caitlin E CornellDepartment of Chemistry, University of Washington, Seattle, Seattle, WA 98195-1700.ORCID 0000-0001-7675-1415
Sarah L KellerDepartment of Chemistry, University of Washington, Seattle, Seattle, WA 98195-1700.ORCID 0000-0001-5919-0185
Paul FrançoisErnest Rutherford Physics Building, McGill University, Montreal, QC H3A 2T8, Canada.ORCID 0000-0002-2223-839X
Adam G HendricksDepartment of Bioengineering, McGill University, Montreal, QC H3A 0C3, Canada.ORCID 0000-0003-3635-1577
Allen J EhrlicherDepartment of Bioengineering, McGill University, Montreal, QC H3A 0C3, Canada.ORCID 0000-0003-3030-979X
Rohit V PappuDepartment of Biomedical Engineering and Center for Science and Engineering of Living Systems, Washington University in St. Louis, St. Louis, MO 63130; pappu@wustl.edu stephen.michnick@umontreal.ca.ORCID 0000-0003-2568-1378
Stephen W MichnickDépartement de Biochimie, Université de Montréal, Montréal, QC H3C 3J7, Canada; pappu@wustl.edu stephen.michnick@umontreal.ca.
McGill University · CAUniversité de Montréal · CAUniversity of Washington · USWashington University in St. Louis · US

Funding

TRAINING IN MOLECULAR BIOPHYSICST32GM008268 · NIGMS · UNIVERSITY OF WASHINGTON · PI KOLLMAN, JUSTIN M, ZHENG, NING · 1988 to 2023
$8.6M
ROLE OF CHAIN LENGTH AND SEQUENCE CONTEXTS ON POLYGLUTAMINE OLIGOMERIZATIONR01NS056114 · NINDS · WASHINGTON UNIVERSITY · PI PAPPU, ROHIT V · 2007 to 2020
$4.4M
CIHR MOP-GMX-152556NIGMS NIH HHS T32 GM008268NINDS NIH HHS R01 NS056114
6 · The paper itself

Abstract

Membrane invagination and vesicle formation are key steps in endocytosis and cellular trafficking. Here, we show that endocytic coat proteins with prion-like domains (PLDs) form hemispherical puncta in the budding yeast,

Indexed as

Cell MembraneCytoskeletal ProteinsCytosolEndocytosisGene Expression Regulation, FungalGlutamineMechanotransduction, CellularPrionsProtein ConformationSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsViscoelastic SubstancesCytoskeletal ProteinsGlutaminePrionsSaccharomyces cerevisiae ProteinsSLA1 protein, S cerevisiaeViscoelastic Substancesbiomolecular condensatesendocytosisprotein–protein interactionsviscoelasticity

Identifiers

PMID34887356
PMCPMC8685726
OpenAlexW4200163156

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.