Evidence map›Paper›PMID 34887354›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death.

Rosalind L Ang, Mark Chan, Diana Legarda, John P Sundberg, Shao-Cong Sun, Virginia L Gillespie, Nicholas Chun, Peter S Heeger, Huabao Xiong, Sergio A Lira and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. CYLD in health and disease.Disease models & mechanisms · 2023
    Review
  7. Article
  8. Review
  9. Deubiquitinases: Modulators of Different Types of Regulated Cell Death.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Rosalind L AngPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029; rang.phd776@gmail.com ting.adrian@mayo.edu.
Mark ChanPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0001-9284-1680
Diana LegardaPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0003-3177-129X
John P SundbergThe Jackson Laboratory, Bar Harbor, ME 04609.
Shao-Cong SunDepartment of Immunology, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030.ORCID 0000-0001-7353-9400
Virginia L GillespieCenter for Comparative Medicine and Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Nicholas ChunPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0001-6884-3686
Peter S HeegerPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0003-4673-6913
Huabao XiongPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0003-0180-2104
Sergio A LiraPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Adrian T TingPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029; rang.phd776@gmail.com ting.adrian@mayo.edu.ORCID 0000-0003-0653-9923
Icahn School of Medicine at Mount Sinai · USMayo Clinic in Arizona · USJackson Laboratory · USThe University of Texas MD Anderson Cancer Center · US

Funding

THE ROLE OF ICSBP IN MUCOSAL IMMUNE RESPONSEP01DK072201 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HARPAZ, NOAM · 2006 to 2015
$14.6M
Teaching biomedical and pharmacological trainees to produce FAIR data for AI & ML applicationsT32GM062754 · NIGMS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SCHLESSINGER, AVNER · 2001 to 2023
$6.2M
Cpdm: Cloning a Gene That Regulates Eosinophil FunctionR01AR049288 · NIAMS · JACKSON LABORATORY · PI BOWCOCK, ANNE MARY, HOGENESCH, HARM · 2004 to 2016
$5.9M
Regulation of TNF Receptor-mediated Cell DeathR01AI052417 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI TING, ADRIAN T · 2002 to 2020
$5.9M
Mechanisms associated with flares and remission in colitisR01DK110352 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LIRA, SERGIO A. · 2017 to 2025
$5.1M
Translational Immunology Training ProgramT32AI078892 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Karen Leigh Edelblum, SERGIO A. LIRA · 2008 to 2026
$4.5M
Molecular pathogenesis of intestinal serrated polypsR01CA161373 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LIRA, SERGIO A. · 2011 to 2020
$3.7M
Signaling Functions of the Tumor Suppressor CYLDR01AI064639 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SUN, SHAO-CONG · 2006 to 2014
$3.6M
Cell Death Pathways and Heart Transplant RejectionR01AI132405 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HEEGER, PETER SCOTT, TING, ADRIAN T · 2017 to 2021
$2.8M
Regulation of T-cell function and autoimmune inflammation by deubiquitinases.R37AI064639 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SUN, SHAO-CONG · 2015 to 2021
$2.8M
Mechanisms associated with diet-induced colitisR01DK121009 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LIRA, SERGIO A. · 2020 to 2023
$2.4M
Regulation of TNF Receptor-Mediated ApoptosisR56AI052417 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TING, ADRIAN T · 2008 to 2008
$424k
NCI NIH HHS R01 CA161373NIAID NIH HHS R01 AI052417NIAID NIH HHS R01 AI064639NIAID NIH HHS R01 AI132405NIAID NIH HHS R37 AI064639NIAID NIH HHS R56 AI052417NIAID NIH HHS R56 AI104521NIAID NIH HHS T32 AI078892NIAMS NIH HHS R01 AR049288NIDDK NIH HHS P01 DK072201NIDDK NIH HHS R01 DK110352NIDDK NIH HHS R01 DK121009NIGMS NIH HHS T32 GM062754
6 · The paper itself

Abstract

SHARPIN, together with RNF31/HOIP and RBCK1/HOIL1, form the linear ubiquitin chain assembly complex (LUBAC) E3 ligase that catalyzes M1-linked polyubiquitination. Mutations in

Indexed as

AnimalsCell DeathDeubiquitinating Enzyme CYLDEmbryo, MammalianFemaleFibroblastsGene Expression RegulationInflammationIntracellular Signaling Peptides and ProteinsMaleMiceMice, KnockoutMyeloid CellsPhosphorylationSkin DiseasesUbiquitinationCYLD protein, mouseDeubiquitinating Enzyme CYLDIntracellular Signaling Peptides and ProteinsSipl1 protein, mouseapoptosisinflammationripoptocideTNFubiquitin

Identifiers

PMID34887354
PMCPMC8685717
OpenAlexW4226146004

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.