Evidence map›Paper›PMID 34886907›Full record

SynthesisJournal of physiological anthropology2021

Risk factors of asthma in the Asian population: a systematic review and meta-analysis.

Yang Yie Sio, Fook Tim Chew

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of physiological anthropology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 5 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 51 citations in OpenAlex.

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  4. Identifying risk factors for COPD and adult-onset asthma: an umbrella review.European respiratory review : an official journal of the European Respiratory Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yang Yie SioAllergy and Molecular Immunology Laboratory, Lee Hiok Kwee Functional Genomics Laboratories, Department of Biological Sciences, National University of Singapore, Block S2, Level 5, 14 Science Drive 4, off Lower Kent Ridge Road, 117543, Singapore, Singapore.
Fook Tim ChewAllergy and Molecular Immunology Laboratory, Lee Hiok Kwee Functional Genomics Laboratories, Department of Biological Sciences, National University of Singapore, Block S2, Level 5, 14 Science Drive 4, off Lower Kent Ridge Road, 117543, Singapore, Singapore. dbscft@nus.edu.sg.ORCID http://orcid.org/0000-0003-1337-5146
National University of Singapore · SG

Funding

Agency for Science Technology and Research (A*STAR) (Singapore) H17/01/a0/008Biomedical Research Council BMRC/01/1/21/18/077Biomedical Research Council BMRC/04/1/21/19/315Biomedical Research Council BMRC/APG2013/108Faculty of Science, National University of Singapore N-154-000-038-001National Medical Research Council NMRC/1150/2008NUS Resilience & Growth Postdoctoral Fellowships R-141-000-036-281Singapore Immunology Network SIgN-06-006Singapore Immunology Network SIgN-08-020Singapore Ministry of Education Academic Research Fund R-154-000-191-112Singapore Ministry of Education Academic Research Fund R-154-000-404-112Singapore Ministry of Education Academic Research Fund R-154-000-553-112Singapore Ministry of Education Academic Research Fund R-154-000-565-112Singapore Ministry of Education Academic Research Fund R-154-000-630-112Singapore Ministry of Education Academic Research Fund R-154-000-A08-592Singapore Ministry of Education Academic Research Fund R-154-000-A27-597Singapore Ministry of Education Academic Research Fund R-154-000-A91-592Singapore Ministry of Education Academic Research Fund R-154-000-A95-592Singapore Ministry of Education Academic Research Fund R-154-000-B99-114
6 · The paper itself

Abstract

BACKGROUND AND

objectiveAn increasing trend of asthma prevalence was observed in Asia; however, contributions of environmental and host-related risk factors to the development of this disease remain uncertain. This study aimed to perform a systematic review and meta-analysis for asthma-associated risk factors reported in Asia.

methodsWe systematically searched three public databases (Web of Science, PubMed, and Scopus) in Feb 2021. We only included articles that reported environmental and host-related risk factors associated with asthma in the Asian population. Random-effect meta-analyses were conducted for frequently reported asthma-associated risk factors to provide an overall risk estimate of asthma development.

resultsOf 4030 records obtained from public databases, 289 articles were selected for review. The most frequently reported asthma-associated risk factor was the family history of allergy-related conditions. The random-effect asthma risk estimates (pooled odds ratio, OR) were 4.66 (95% confidence interval (CI): 3.73-5.82) for the family history of asthma, 3.50 (95% CI: 2.62-4.67) for the family history of atopy, 3.57 (95% CI: 3.03-4.22) for the family history of any allergic diseases, 1.96 (95% CI: 1.47-2.61) for the family history of allergic rhinitis, and 2.75 (95% CI: 1.12-6.76) for the family history of atopic dermatitis. For housing-related factors, including the presence of mold, mold spots, mold odor, cockroach, water damage, and incense burning, the random-effect pooled OR ranged from 1.43 to 1.73. Other risk factors with significant pooled OR for asthma development included male gender (1.30, 95% CI: 1.23-1.38), cigarette smoke exposure (1.44, 95% CI: 1.30-1.60), cigarette smoking (1.66, 95% CI: 1.44-1.90), body mass index (BMI)-related parameters (pooled OR ranged from 1.06 to 2.02), various types of air pollution (NO

conclusionsThe family history of asthma was the most frequently reported risk factor for asthma development in Asia with the highest risk estimate for asthma development. This suggests a major role of the genetic component in asthma pathogenesis. Further study on asthma genetics is required to improve the current understanding of asthma etiology.

Indexed as

AsthmaAsian PeopleCesarean SectionFemaleHumansInfant, NewbornMalePregnancyPremature BirthPrevalenceRisk FactorsAsthmaMeta-analysisReviewRisk

Identifiers

PMID34886907
PMCPMC8662898
OpenAlexW4200409034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.