ArticleBMC medicine2021
Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort.
Article in BMC medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Prospective study of circulating metabolomic profiles and breast cancer incidence among predominantly premenopausal women.British journal of cancer · 2025Observational
- Metabolomic Analysis of Breast Cancer in Colombian Patients: Exploring Molecular Signatures in Different Subtypes and Stages.International journal of molecular sciences · 2025Article
- Metabolic profile of biodiverse diets in a healthy European cohort.The American journal of clinical nutrition · 2025Article
- Metabolite Predictors of Breast and Colorectal Cancer Risk in the Women's Health Initiative.Metabolites · 2024Article
- Comprehensive serum lipidomic analyses reveal potential biomarkers for malignant breast cancer: A case-control study.Cancer biomarkers : section A of Disease markers · 2023Article
- Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer.Nutrients · 2022Article
- Comprehensive metabolomic characterization of atrial fibrillation.Frontiers in cardiovascular medicine · 2022Article
- Impact of Lifestyle Interventions on Gynecologic Cancers: Beyond Diet and Exercise.American journal of lifestyle medicineReview
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Authors and funding
36 authors at 20 institutions in 10 countries.
Funding
Abstract
backgroundMetabolomics is a promising molecular tool for identifying novel etiological pathways leading to cancer. In an earlier prospective study among pre- and postmenopausal women not using exogenous hormones, we observed a higher risk of breast cancer associated with higher blood concentrations of one metabolite (acetylcarnitine) and a lower risk associated with higher blood concentrations of seven others (arginine, asparagine, phosphatidylcholines (PCs) aa C36:3, ae C34:2, ae C36:2, ae C36:3, and ae C38:2).
methodsTo identify determinants of these breast cancer-related metabolites, we conducted a cross-sectional analysis to identify their lifestyle and anthropometric correlates in 2358 women, who were previously included as controls in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition cohort and not using exogenous hormones at blood collection. Associations of each metabolite concentration with 42 variables were assessed using linear regression models in a discovery set of 1572 participants. Significant associations were evaluated in a validation set (n = 786).
resultsFor the metabolites previously associated with a lower risk of breast cancer, concentrations of PCs ae C34:2, C36:2, C36:3, and C38:2 were negatively associated with adiposity and positively associated with total and saturated fat intakes. PC ae C36:2 was also negatively associated with alcohol consumption and positively associated with two scores reflecting adherence to a healthy lifestyle. Asparagine concentration was negatively associated with adiposity. Arginine and PC aa C36:3 concentrations were not associated to any of the factors examined. For the metabolite previously associated with a higher risk of breast cancer, acetylcarnitine, a positive association with age was observed.
conclusionsThese associations may indicate possible mechanisms underlying associations between lifestyle and anthropometric factors, and risk of breast cancer. Further research is needed to identify potential non-lifestyle correlates of the metabolites investigated.
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