Observational studyBMC pediatrics2021
Brain and renal oxygenation measured by NIRS related to patent ductus arteriosus in preterm infants: a prospective observational study.
Observational study in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04295395 (Evaluation of the Brain and Renal Regional Oxygenation Using Near Infrared Spectroscopy), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Brain and Renal Regional Oxygenation Using Near Infrared Spectroscopy (NIRS) Method in Very Low Birth Weight (<1500 g) Infants
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Regional oxygen saturation as a non-invasive indicator for neonatal PDA: a systematic review and meta-analysis.BMC pediatrics · 2026Pooled it
- Predictive value of cerebral doppler resistive index in premature infants with hemodynamically significant patent ductus arteriosus.BMC pediatrics · 2026Article
- Cerebral hemodynamic changes in neonates with different types of patent ductus arteriosus: a study using transcranial Doppler ultrasound.BMC pediatrics · 2026Article
- Lung ultrasound evolution after interventional closure of the ductus in preterm babies.European journal of pediatrics · 2026Observational
- Clinical Impact of the PDA and Its Management on Outcomes of Preterm Infants with NEC: A Review.American journal of perinatology · 2026Review
- Cerebral and intestinal Doppler patterns according to patent ductus arteriosus shunt characteristics in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Liver Regional Oxygen Saturation in Preterm Infants with Patent Ductus Arteriosus Status.Biomedicines · 2026Article
- Assessment of vital organ oxygenation by near-infrared spectroscopy in pharmacologic closure therapy for patent ductus arteriosus in preterm neonates.Revista da Associacao Medica Brasileira (1992) · 2026Observational
- The use of near-infrared spectroscopy to measure kidney oxygenation in the neonatal intensive care unit.Pediatric nephrology (Berlin, Germany) · 2025Review
- Impact of catheterized ductal closure on renal and cerebral oximetry in premature neonates.European journal of pediatrics · 2024Observational
- Impact of Early Surfactant Administration on Ductus Arteriosus Assessed at 24 h in Preterm Neonates Less than 32 Weeks of Gestational Age.Biomedicines · 2024Article
- Effects of the feeding protocol during blood transfusion on splanchnic tissue oxygenation and complications in very premature infants.Frontiers in nutrition · 2024Article
- Neonatal acute kidney injury during indomethacin therapy: does it predict ductal closure?Journal of nephrology · 2023Article
- Association of early cerebral oxygen saturation and brain injury in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Impact of Medical Treatment of Hemodynamically Significant Patent Ductus Arteriosus on Cerebral and Renal Tissue Oxygenation Measured by Near-Infrared Spectroscopy in Very Low-Birth-Weight Infants.Medicina (Kaunas, Lithuania) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatent ductus arteriosus (PDA) is common among preterm neonates. Haemodynamically significant ductus arteriosus (hsPDA) can cause ductal steal and contribute to poor outcomes. Our aim was to evaluate ductus arteriosus patency and significance using two-site near-infrared spectroscopy (NIRS) measurements in preterm infants older than 72 h as a supplemental tool to echocardiography.
methodsIn this prospective observational study, 123 preterm infants (gestational age (GA) < 32 weeks, birth weight < 1500 g) were enrolled. Sixty-four newborns had closed ductus arteriosus (noPDA), and 41 and 18 patients were assigned to the PDA and hsPDA groups, respectively, per predefined echocardiographic criteria. Cerebral and renal oxygenation were assessed during NIRS monitoring.
resultsA higher renal mean (±SD) regional tissue oxygen saturation (rSpO
conclusionsOur results suggest that renal oxygenation is affected by ductus patency in preterm infants older than 72 h. Significant differences in cerebral oxygenation were observed between the hsPDA group and the PDA and noPDA groups.
trial registrationClinicalTrials.gov Identifier: NCT04295395. Registration date: 4 March 2020. This study was retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04295395 .
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