ArticleClinical and experimental pediatrics2022
Neonatal sepsis-causing bacterial pathogens and outcome of trends of their antimicrobial susceptibility a 20-year period at a neonatal intensive care unit.
Article in Clinical and experimental pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Pathogenic characterization and drug resistance of neonatal sepsis in China: a systematic review and meta-analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Pooled it
- Using molecular methods to diagnose, classify, and treat neonatal sepsis: a scoping review.Frontiers in pediatrics · 2025Pooled it
- Targeted proteomics in late-onset neonatal sepsis: an exploratory analysis.Pediatric research · 2026Article
- Trends and Interhospital Variability of NICU Bloodstream Infections in Korea.JAMA network open · 2026Article
- Development of a Simple Clinical Risk Score for Mortality Prediction in Neonatal Gram-Negative Sepsis.Indian journal of pediatrics · 2026Article
- Bacteriological profile of early versus late-onset neonatal sepsis at tertiary care hospital in Nepal.BMC infectious diseases · 2026Article
- Trends in pathogens and antimicrobial resistance in culture-proven neonatal sepsis over a decade (2015-2024): the impact of COVID-19 pandemic.Frontiers in cellular and infection microbiology · 2026Observational
- Evaluation of antibiotic consumption and resistance patterns among neonates: a 10-year retrospective study.Frontiers in pediatrics · 2026Article
- Clinical characteristics, bacterial profiles and antimicrobial resistance of neonates with bloodstream infection caused by ESKAPEEc pathogens in Southwest China.BMC infectious diseases · 2025Article
- Neonatal and pediatric sepsis: Microbiological insights, diagnostic innovations, and antimicrobial challenges.World journal of clinical pediatrics · 2025Review
- Characterising commensal and pathogenic staphylococcal interactions with neonatal and adult blood.Scientific reports · 2025Article
- A 10-Year Study of Neonatal Sepsis from Tuen Mun Hospital, Hong Kong.Pathogens (Basel, Switzerland) · 2025Article
- Pathogen distribution, antimicrobial resistance and attributable cost analysis of neonatal sepsis in neonatal intensive care units: a propensity score matching study.Frontiers in pediatrics · 2025Article
- Bloodstream Infections in the Neonatal Intensive Care Unit: A Systematic Review of the Literature.Cureus · 2024Review
- Loop-mediated isothermal amplification (LAMP) assay for early on-site detection of Group B Streptococcus infection in neonatal sepsis blood sample.Molecular biology reports · 2024Article
- Trends in Causative Organisms and Antimicrobial Resistance in Late-onset Neonatal Sepsis.Turkish archives of pediatrics · 2024Article
- A decade of neonatal sepsis in Stockholm, Sweden: Gram-positive pathogens were four times as common as Gram-negatives.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Improving Activity of New Arylurea Agents against Multidrug-Resistant and Biofilm-ProducingACS medicinal chemistry letters · 2024Article
- Article
- New Insights in Immunometabolism in Neonatal Monocytes and Macrophages in Health and Disease.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDue to increases in the number of infants born with younger gestational age (GA) and lower birth weight, the incidence of neonatal sepsis is increasing. PURPOSE: We investigated the changes in the prevalence of bacterial pathogens, their antimicrobial susceptibility, and sepsis-related mortality during 20 years at a neonatal intensive care unit.
methodsThe study period was divided into two 10-year phases (1998-2007 vs. 2008-2017). Medical records were reviewed to gather data on demographics, causative microbial pathogens, incidence of multidrug-resistant organisms, antimicrobial susceptibility, and rates of sepsis-related mortality.
resultsIn both study phases, the most common pathogens for neonatal sepsis were coagulase-negative Staphylococcus (CoNS) (28.6%) and Enterobacter cloacae (16.1%) for early-onset sepsis (EOS, ≤72 hours after birth) and CoNS (54.7%) and Staphylococcus aureus (12.9%) for late-onset sepsis (LOS, >72 hours after birth). CoNS and S. aureus showed 100% sensitivity to vancomycin in both phases. The susceptibility of S. aureus to oxacillin increased from 19.2% to 57.9% in phase II than phase I. K. pneumonia and E. cloacae showed increases in its susceptibility to gentamicin, cefotaxime and ceftriaxone in phase II than phase I. In both phases, the most common pathogens that caused sepsis-related death were K. pneumoniae (18.2%) and Pseudomonas aeruginosa (13.6%). Sepsis-related mortality rate was higher in infants with GA <37 weeks than those with GA over 37 weeks (P=0.016). In addition, the mortality rate of neonatal sepsis caused by gram-negative bacteria was significantly higher than that caused by gram-positive bacteria (P<0.001).
conclusionsCoNS was the most common pathogen for EOS and LOS. While we found significant changes in antimicrobial sensitivities over time. GA below 37 weeks and gram-negative organisms are associated with mortality rate.
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