ArticleInternational journal of environmental research and public health2021
Factors Associated with Unfavourable Treatment Outcomes in Patients with Tuberculosis: A 16-Year Cohort Study (2005-2020), Republic of Karakalpakstan, Uzbekistan.
Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and predictive factors of tuberculosis treatment interruption in the Asia region: a systematic review and meta-analysis.BMJ global health · 2023Pooled it
- Social isolation and overall well-being among cancer survivors in the Cancer Prevention Study-3.Journal of cancer survivorship : research and practice · 2026Article
- Treatment outcomes and risk factors for unfavorable results among older asymptomatic pulmonary tuberculosis patients in China, 2021-2024.BMC geriatrics · 2026Article
- Article
- The Predictive Value of Dynamic Changes in Procalcitonin and C-Reactive Protein in Evaluating Response of Patients with Pulmonary Tuberculosis in the Early Treatment.Infection and drug resistance · 2026Article
- Role of ethnicity and residency in active tuberculosis in Karakalpakstan: study protocol of a matched case-control study.BMJ open respiratory research · 2024Article
- Factors associated with unfavourable treatment outcomes among tuberculosis patients at health facilities of Maseru, Lesotho.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2024Article
- Prediction of tuberculosis-specific mortality for older adult patients with pulmonary tuberculosis.Frontiers in public health · 2024Article
- Recurrent Pneumonia With Tuberculosis andFrontiers in medicine · 2022Article
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Authors and funding
14 authors.
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Abstract
Tuberculosis (TB) remains a public health burden in the Republic of Karakalpakstan, Uzbekistan. This region-wide retrospective cohort study reports the treatment outcomes of patients registered in the TB electronic register and treated with first-line drugs in the TB Programme of the Republic of Karakalpakstan from 2005-2020 and factors associated with unfavourable outcomes. Among 35,122 registered patients, 24,394 (69%) patients were adults, 2339 (7%) were children, 18,032 (51%) were male and 19,774 (68%) lived in rural areas. Of these patients, 29,130 (83%) had pulmonary TB and 7497 (>22%) had been previously treated. There were 7440 (21%) patients who had unfavourable treatment outcomes. Factors associated with unfavourable treatment outcomes included: increasing age, living in certain parts of the republic, disability, pensioner status, unemployment, being HIV-positive, having pulmonary TB, and receiving category II treatment. Factors associated with death included: being adult and elderly, living in certain parts of the republic, having a disability, pensioner status, being HIV-positive, and receiving category II treatment. Factors associated with failure included: being adolescent, female, having pulmonary TB. Factors associated with loss to follow-up included: being male, disability, pensioner status, unemployment, receiving category II treatment. In summary, there are sub-groups of patients who need special attention in order to decrease unfavourable treatment outcomes.
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