Observational studyInternational journal of environmental research and public health2021
Duration of Untreated Disorder and Cannabis Use: An Observational Study on a Cohort of Young Italian Patients Experiencing Psychotic Experiences and Dissociative Symptoms.
Observational study in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The severity of dissociation and dissociative phenomena in non-affective psychosis: a systematic review and meta-analyses.BMC psychiatry · 2026Pooled it
- Symptom severity and cognitive performance in patients with substance induced psychotic disorder and schizophrenia: a cross-sectional comparative study.Schizophrenia research. Cognition · 2025Article
- Exploring emerging psychopathological characteristics and challenges of novel depression subtypes: insights from the literature.Frontiers in psychiatry · 2025Review
- Development and initial validation of the cannabis-related psychosis risk literacy scale (CPRL): a multinational psychometric study.BMC psychiatry · 2024Article
- UK Medical Cannabis Registry: Assessment of clinical outcomes in patients with insomnia.Brain and behavior · 2024Article
- Using Task-fMRI to Explore the Relationship Between Lifetime Cannabis Use and Cognitive Control in Individuals With First-Episode Schizophrenia.Schizophrenia bulletin open · 2024Article
- Association between cannabis use and symptom dimensions in schizophrenia spectrum disorders: an individual participant data meta-analysis on 3053 individuals.EClinicalMedicine · 2023Article
- Aberrant salience in cannabis-induced psychosis: a comparative study.Frontiers in psychiatry · 2023Article
- Synthetic cannabinoids awareness among patients with opioid use disorder in Serbia - A survey based cross-sectional pilot study.Frontiers in psychiatry · 2023Article
- Remission with or without comorbid substance use disorders in early psychosis: long-term outcome in integrated care (ACCESS III study).Frontiers in psychology · 2023Article
- Lurasidone use in Cannabis-Induced Psychosis: A Novel Therapeutic Strategy and Clinical Considerations in Four Cases Report.International journal of environmental research and public health · 2022Article
- Association of Polymorphism within the Putative miRNA Target Site in the 3'UTR Region of theInternational journal of environmental research and public health · 2022Article
- Maladaptive Personality Traits in a Group of Patients with Substance Use Disorder and ADHD.Medicina (Kaunas, Lithuania) · 2022Article
- Medical cannabis for treatment-resistant combat PTSD.Frontiers in psychiatry · 2022Article
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13 authors.
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Abstract
backgroundThe Duration of Untreated Psychosis (DUP) is the time between the first-episode psychosis (FEP) and the initiation of antipsychotic treatment. It is an important predictor of several disease-related outcomes in psychotic disorders. The aim of this manuscript is investigating the influence of cannabis on the DUP and its clinical correlates.
methodsDuring years 2014-2019, sixty-two FEP patients with and without cannabis use disorder (CUD) were recruited from several Italian psychiatric hospitals. The subjects were then divided into two groups based on the duration of the DUP and assessed at the beginning of the antipsychotic treatment and after 3 and 6 months, using the Positive and Negative Syndrome Scale (PANSS), the Global Assessment of Functioning (GAF) scale, and the Dissociative Experiences Scale (DES-II).
resultsAs expected, a longer DUP was associated with worse symptoms and cannabis use did not seem to affect the DUP, but both were related with more dissociative symptoms at onset and over time. DISCUSSION: According to our study, cannabis use can be a predictor of FEP and DUP, and of disease outcome. However, several factors might influence the relationship between cannabis use and DUP. Preventing cannabis use and early diagnosis of psychotic disorders might impact the disease by reducing the persistence of symptoms and limiting dissociative experiences.
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