ArticleInternational journal of environmental research and public health2021
Use of Antibiotic Treatment in Pregnancy and the Risk of Several Neonatal Outcomes: A Population-Based Study.
Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Prevalence of systemic antibacterial use during pregnancy worldwide: A systematic review.PloS one · 2024Pooled it
- Patterns of Antibiotic Dispensing Among New Zealand Children: A Linkage Study.Pharmacoepidemiology and drug safety · 2026Article
- Maternal Vaccine Receipt and Infant Hospital and Emergency Visits for Influenza and Pertussis.JAMA network open · 2026Article
- Co-trimoxazole-induced reproductive toxicity and placental-barrier disruption: impact on cell-cell junctions and ERK signaling pathway.Frontiers in cell and developmental biology · 2026Article
- Penicillin Disrupts Dental Mineralization in Rats: A Comparative Study With Tetracycline Highlighting Prenatal and Postnatal Risks.Clinical and experimental dental research · 2025Article
- Influence of perinatal antibiotic on neonatal gut microbiota: a prospective cohort study.BMC pediatrics · 2025Article
- Prenatal and Early Childhood Exposure to Proton Pump Inhibitors and Antibiotics and the Risk of Childhood Cancer: A Nationwide Population-Based Cohort Study.Drug safety · 2025Article
- The hazard of using the Poisson model to cope with immortal time bias in the case of time-varying hazard.BMC medical research methodology · 2024Article
- Impact of Genital Infections and Antibiotic Use on Incidence of Preterm Birth: A Retrospective Observational Study.Antibiotics (Basel, Switzerland) · 2024Article
- Serum cytokines in second trimester pregnancy and their relationship with spontaneous preterm births in the Ribeirão Preto and São Luiz cohorts.BMC pregnancy and childbirth · 2023Article
- Antibiotic Use in Pregnancy: A Global Survey on Antibiotic Prescription Practices in Antenatal Care.Antibiotics (Basel, Switzerland) · 2023Article
- Predictors of antibiotic use in pregnant women attending Najran University Hospital, Saudi Arabia.Saudi medical journal · 2023Article
- Antibiotic Use During Pregnancy and Childbirth: Prospective Observational Study on Prevalence, Indications, and Prescribing Patterns in a German Tertiary Center.Geburtshilfe und Frauenheilkunde · 2023Article
- Prevalence, predictors and pregnancy outcomes of unprescribed and herbal medicine use in Ibadan, Nigeria.BMC complementary medicine and therapies · 2023Article
- Big Data, Decision Models, and Public Health.International journal of environmental research and public health · 2022Article
- Does the Fetus Limit Antibiotic Treatment in Pregnant Patients with COVID-19?Antibiotics (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLimited evidence is available on the safety and efficacy of antimicrobials during pregnancy, with even less according to the trimester of their use.
objectiveThis study aimed to evaluate the association between exposure to antibiotics therapy (AT) during pregnancy and short-term neonatal outcomes.
methodsWe considered 773,237 deliveries that occurred between 2007-2017 in the Lombardy region of Italy. We evaluated the risk of neonatal outcomes among infants that were born to mothers who underwent AT during pregnancy. The odds ratios and the hazard ratios, with the 95% confidence intervals, were estimated respectively for early (first/second trimester) and late (third trimester) exposure. The propensity score was used to account for potential confounders. We also performed subgroup analysis for the class of AT.
resultsWe identified 132,024 and 76,921 singletons that were exposed to AT during early and late pregnancy, respectively. Infants born to mothers with early exposure had 17, 11, and 16% increased risk of preterm birth, low birth weight, and low Apgar score, respectively. Infants that were exposed in late pregnancy had 25, 11, and 13% increased risk of preterm birth, low birth weight, and low Apgar score, respectively. The results were consistent in the subgroup analysis.
conclusionOur results suggested an increased risk of several neonatal outcomes in women exposed to ATs during pregnancy, albeit we were not able to assess to what extent the observed effects were due to the infection itself. To reduce the risk of neonatal outcomes, women that are prescribed AT during pregnancy should be closely monitored.
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