Evidence map›Paper›PMID 34886257›Full record

ArticleInternational journal of environmental research and public health2021

A Lower CD4 Count Predicts Most Causes of Death except Cardiovascular Deaths. The Austrian HIV Cohort Study.

Gisela Leierer, Armin Rieger, Brigitte Schmied, Mario Sarcletti, Angela Öllinger, Elmar Wallner, Alexander Egle, Manfred Kanatschnig, Alexander Zoufaly, Michele Atzl and 5 more

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 2 countries.

Gisela LeiererDepartment of Dermatology and Venereology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Armin RiegerDivision of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, 1090 Vienna, Austria.
Brigitte SchmiedOtto-Wagner Hospital, 1140 Vienna, Austria.
Mario SarclettiDepartment of Dermatology and Venereology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Angela ÖllingerDepartment of Dermatology, Med. Campus III, Kepler University Hospital Linz, Johannes Kepler University Linz, 4040 Linz, Austria.
Elmar WallnerDepartment of Internal Medicine, General Hospital Graz South-West, 8020 Graz, Austria.
Alexander EgleDepartment of Internal Medicine III with Hematology, Medical Oncology, Hemostaseology, Infectious Diseases, Rheumatology, Oncologic Center, Laboratory for Immunological and Molecular Cancer Research, Paracelsus Medical University, 5020 Salzburg, Austria.
Manfred Kanatschnig1st Medical Department, General Hospital Klagenfurt, 9020 Klagenfurt, Austria.
Alexander ZoufalyKaiser-Franz-Josef Hospital Vienna, 1100 Vienna, Austria.
Michele AtzlDepartment of Internal Medicine, Oncology, Haematology, Infectious Diseases, State Hospital Feldkirch, 6800 Feldkirch, Austria.
Michaela RappoldDepartment of Dermatology and Venereology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Ziad El-KhatibDepartment of Surveillance and Infectious Disease Epidemiology, Austrian Agency for Health and Food Safety (AGES), Austrian Ministry for Health, Ministry of Sustainability and Tourism, 1220 Vienna, Austria.
Bruno LedergerberDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, 8006 Zurich, Switzerland.ORCID 0000-0002-6881-4401
Robert ZangerleDepartment of Dermatology and Venereology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-5375-7299
On Behalf Of The Austrian Hiv Cohort Study Group
Innsbruck Medical University · ATAustrian Agency for Health and Food Safety · ATGraz University Hospital · ATKaiser-Franz-Josef-Spital · ATKlinikum Klagenfurt · ATLandeskrankenhaus Feldkirch · ATMedical University of Vienna · ATOtto Wagner Hospital · ATParacelsus Medical University · ATUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Objective: To investigate changes in mortality rates and predictors of all-cause mortality as well as specific causes of death over time among HIV-positive individuals in the combination antiretroviral therapy (cART) era. (2) Methods: We analyzed all-cause as well as cause-specific mortality among the Austrian HIV Cohort Study between 1997 and 2014. Observation time was divided into five periods: Period 1: 1997-2000; period 2: 2001-2004; period 3: 2005-2008; period 4: 2009-2011; and period 5: 2012-2014. Mortality rates are presented as deaths per 100 person-years (d/100py). Potential risk factors associated with all-cause mortality and specific causes of death were identified by using multivariable Cox proportional hazard models. Models were adjusted for time-updated CD4, age and cART, HIV transmission category, population size of residence area and country of birth. To assess potential nonlinear associations, we fitted all CD4 counts per patient using restricted cubic splines with truncation at 1000 cells/mm

Indexed as

HIV InfectionsAustriaCause of DeathCD4 Lymphocyte CountCohort StudiesHumansRisk FactorscARTcause-specific mortalityCD4cohort studyrisk factors

Identifiers

PMID34886257
PMCPMC8656512
OpenAlexW3215060608

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.