Evidence map›Paper›PMID 34886114›Full record

ArticleInternational journal of environmental research and public health2021

Gamified Dual-Task Training for Individuals with Parkinson Disease: An Exploratory Study on Feasibility, Safety, and Efficacy.

Lee-Kuen Chua, Yu-Chen Chung, David Bellard, Laura Swan, Nicole Gobreial, Amanda Romano, Ryan Glatt, Michael A Bonaguidi, Darrin J Lee, Yi Jin and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06838741 (Comparison of Effects of Virtual Reality and Otago Exercises on Balance, Gait and Activities of Daily Living in Parkinson's Disease Patients.), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06838741 naenrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Comparison of Effects of Virtual Reality and Otago Exercises on Balance, Gait and Activities of Daily Living in Parkinson's Disease Patients.

TypeinterventionalSponsorRiphah International UniversityRan2024 to 2025Enrolled74ConditionsParkinson DiseaseArmsotago exercises, virtual reality
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lee-Kuen ChuaUSC Neurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0003-4774-5387
Yu-Chen ChungDepartment of Physical Medicine and Rehabilitation, UT Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-8408-4341
David BellardDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA 90033, USA.
Laura SwanDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA 90033, USA.
Nicole GobreialDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA 90033, USA.
Amanda RomanoUSC Neurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Ryan GlattPacific Brain Health Center, Pacific Neuroscience Institute, Santa Monica, CA 90404, USA.
Michael A BonaguidiUSC Neurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Darrin J LeeUSC Neurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Yi JinBrain Health Leadership Foundation, Reno, NV 89509, USA.
Charles Y LiuUSC Neurorestoration Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Beth E FisherDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA 90033, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe feasibility and safety of the use of neurorehabilitation technology (SMARTfit

methodsUsing a cross-over study design, eight participants with mild-to-moderate idiopathic PD (including one with mild cognitive impairment) completed both training conditions (i.e., gamified DTT and STT). For each training condition, the participants attended 2-3 sessions per week over 8.8 weeks on average, with the total amount of training being equivalent to 24 1 h sessions. A washout period averaging 11.5 weeks was inserted between training conditions. STT consisted of task-oriented training involving the practice of functional tasks, whereas for gamified DTT, the same task-oriented training was implemented simultaneously with varied cognitive games using an interactive training system (SMARTfit

resultsGamified DTT was feasible and safe for this cohort. Across participants, significant improvements were achieved in more outcome measures after gamified DTT than they were after STT. Individually, participants with specific demographic and clinical characteristics responded differently to the two training conditions.

conclusionPhysical therapists' utilization of technology with versatile hardware configurations and customizable software application selections was feasible and safe for implementing a tailor-made intervention and for adapting it in real-time to meet the individualized, evolving training needs of IWPD. Specifically in comparison to optimized STT, there was a preliminary signal of efficacy for gamified DTT in improving motor and cognitive function as well as perceived disability in IWPD.

Indexed as

Cognitive DysfunctionParkinson DiseaseActivities of Daily LivingCross-Over StudiesFeasibility StudiesHumansexergaminggamified rehabilitationintegrated dual-task trainingmotor-cognitive trainingneurological rehabilitationneurotechnologyoptimized interventionParkinson’s diseasepatient-focused interventionphysical therapy modalities

Identifiers

PMID34886114
PMCPMC8657071

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.