Evidence map›Paper›PMID 34885982›Full record

ArticleMolecules (Basel, Switzerland)2021

Computational Screening for the Anticancer Potential of Seed-Derived Antioxidant Peptides: A Cheminformatic Approach.

Tsun-Thai Chai, Jiun-An Koh, Clara Chia-Ci Wong, Mohamad Zulkeflee Sabri, Fai-Chu Wong

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  6. Review
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  9. Review
  10. Redox Active Molecules in Cancer Treatments.Molecules (Basel, Switzerland) · 2023
    Article
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  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Tsun-Thai ChaiDepartment of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar 31900, Malaysia.ORCID 0000-0003-3716-1599
Jiun-An KohDepartment of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar 31900, Malaysia.ORCID 0000-0001-7534-5490
Clara Chia-Ci WongDepartment of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar 31900, Malaysia.ORCID 0000-0003-2253-2473
Mohamad Zulkeflee SabriGreen Chemistry and Sustainable Technology Cluster, Bioengineering Section, Universiti Kuala Lumpur Malaysian Institute of Chemical and Bioengineering Technology (UniKL MICET), Lot 1988, Bandar Vendor Taboh Naning, Alor Gajah 78000, Malaysia.ORCID 0000-0002-1005-5043
Fai-Chu WongDepartment of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar 31900, Malaysia.ORCID 0000-0003-2259-1617
Universiti Tunku Abdul Rahman · MYUniversity of Kuala Lumpur · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some seed-derived antioxidant peptides are known to regulate cellular modulators of ROS production, including those proposed to be promising targets of anticancer therapy. Nevertheless, research in this direction is relatively slow owing to the inevitable time-consuming nature of wet-lab experimentations. To help expedite such explorations, we performed structure-based virtual screening on seed-derived antioxidant peptides in the literature for anticancer potential. The ability of the peptides to interact with myeloperoxidase, xanthine oxidase, Keap1, and p47

Indexed as

Antineoplastic AgentsAntioxidantsCatalytic DomainCheminformaticsDrug DiscoveryDrug StabilityHumansKelch-Like ECH-Associated Protein 1Molecular Docking SimulationMolecular Dynamics SimulationPeptidesPeroxidasePlant ExtractsProtein BindingSeedsXanthine OxidaseAntineoplastic AgentsAntioxidantsKEAP1 protein, humanKelch-Like ECH-Associated Protein 1MPO protein, humanPeptidesPeroxidasePlant ExtractsXanthine Oxidaseanticancercheminformaticsin silicoKeap1molecular dockingmolecular dynamicsmyeloperoxidaseNADPH oxidaseseed antioxidant peptidexanthine oxidase

Identifiers

PMID34885982
PMCPMC8659047
OpenAlexW4200047710

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.