Evidence map›Paper›PMID 34885946›Full record

ArticleMolecules (Basel, Switzerland)2021

Effect of S-Se Bioisosteric Exchange on Affinity and Intrinsic Efficacy of Novel

Júlia Galvez Bulhões Pedreira, Rafaela Ribeiro Silva, François G Noël, Eliezer J Barreiro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Júlia Galvez Bulhões PedreiraLaboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21944-971, Brazil.
Rafaela Ribeiro SilvaLaboratory of Biochemical and Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21944-971, Brazil.
François G NoëlLaboratory of Biochemical and Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21944-971, Brazil.
Eliezer J BarreiroLaboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21944-971, Brazil.ORCID 0000-0003-1759-0038

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88887.3182253/2019-00 and 88887.318248/2019-00Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/010.000090/2018National Council for Scientific and Technological Development 104.047/2018-6National Institute of Science and Technology of Drugs and Medicines 465.249/2014-0
6 · The paper itself

Abstract

In this work, we evaluated the conformational effect promoted by the isosteric exchange of sulfur by selenium in the heteroaromatic ring of new

Indexed as

Adenosine A2 Receptor AgonistsAnimalsHumansHydrazonesMaleModels, MolecularRatsRats, WistarReceptor, Adenosine A2ASeleniumSulfurThiophenesAdenosine A2 Receptor AgonistsHydrazonesLASSBio 294LASSBio-785Receptor, Adenosine A2ASeleniumSulfurThiophenesA2A receptorchalcogen interactionconformational effectN-acylhydrazone derivativesN-methylation effectsulfur-selenium isosterism

Identifiers

PMID34885946
PMCPMC8659164

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.