Evidence map›Paper›PMID 34885944›Full record

ArticleMolecules (Basel, Switzerland)2021

Seriniquinones as Therapeutic Leads for Treatment of BRAF and NRAS Mutant Melanomas.

Amanda S Hirata, Paula Rezende-Teixeira, João Agostinho Machado-Neto, Paula C Jimenez, James J La Clair, William Fenical, Leticia V Costa-Lotufo

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Amanda S HirataDepartment of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-900, SP, Brazil.ORCID 0000-0001-8480-9875
Paula Rezende-TeixeiraDepartment of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-900, SP, Brazil.ORCID 0000-0003-4138-8040
João Agostinho Machado-NetoDepartment of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-900, SP, Brazil.
Paula C JimenezInstitute of Marine Science, Federal University of São Paulo, Santos 11070-100, SP, Brazil.ORCID 0000-0002-5244-9761
James J La ClairDepartment of Chemistry and Biochemistry, University of California, La Jolla, San Diego, CA 92093-0358, USA.
William FenicalCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, La Jolla, San Diego, CA 92093-0204, USA.
Leticia V Costa-LotufoDepartment of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-900, SP, Brazil.ORCID 0000-0003-1861-5153
Universidade de São Paulo · BRScripps Institution of Oceanography · USUniversidade Federal de São Paulo · BRUniversity of California San Diego · US

Funding

National Council for Scientific and Technological Development 443281/2019-0, 306913/2017-8São Paulo Research Foundation 2016/10854-5, 2018/07661-6, 2020/06613-8, 2015/17177-6, 2019/23864-7
6 · The paper itself

Abstract

Isolated from the marine bacteria

Indexed as

Antineoplastic AgentsApoptosisAutophagyCell Line, TumorDrug DiscoveryGTP PhosphohydrolasesHumansMelanomaMembrane ProteinsMutationProto-Oncogene Proteins B-rafQuinonesSerineAntineoplastic AgentsBRAF protein, humanGTP PhosphohydrolasesMembrane ProteinsNRAS protein, humanProto-Oncogene Proteins B-rafQuinonesSerineantitumor agentapoptosisautophagydermcidindrug discoverymarine pharmacologynatural products

Identifiers

PMID34885944
PMCPMC8658889
OpenAlexW4200099795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.