Evidence map›Paper›PMID 34885892›Full record

ArticleMolecules (Basel, Switzerland)2021

Mathematical Analysis of Reaction-Diffusion Equations Modeling the Michaelis-Menten Kinetics in a Micro-Disk Biosensor.

Naveed Ahmad Khan, Fahad Sameer Alshammari, Carlos Andrés Tavera Romero, Muhammad Sulaiman, Ghaylen Laouini

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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  5. Analysis of heat transmission in convective, radiative and moving rod with thermal conductivity using meta-heuristic-driven soft computing technique.Structural and multidisciplinary optimization : journal of the International Society for Structural and Multidisciplinary Optimization · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Naveed Ahmad KhanDepartment of Mathematics, Abdul Wali Khan University, Mardan 23200, Pakistan.ORCID 0000-0002-8680-723X
Fahad Sameer AlshammariDepartment of Mathematics, College of Science and Humanities in Alkharj, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.ORCID 0000-0002-5402-8960
Carlos Andrés Tavera RomeroCOMBA R&D Laboratory, Faculty of Engineering, Universidad Santiago de Cali, Cali 76001, Colombia.ORCID 0000-0002-4606-7222
Muhammad SulaimanDepartment of Mathematics, Abdul Wali Khan University, Mardan 23200, Pakistan.ORCID 0000-0002-4040-6211
Ghaylen LaouiniCollege of Engineering and Technology, American University of the Middle East, Egaila 54200, Kuwait.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we have investigated the mathematical model of an immobilized enzyme system that follows the Michaelis-Menten (MM) kinetics for a micro-disk biosensor. The film reaction model under steady state conditions is transformed into a couple differential equations which are based on dimensionless concentration of hydrogen peroxide with enzyme reaction (H) and substrate (S) within the biosensor. The model is based on a reaction-diffusion equation which contains highly non-linear terms related to MM kinetics of the enzymatic reaction. Further, to calculate the effect of variations in parameters on the dimensionless concentration of substrate and hydrogen peroxide, we have strengthened the computational ability of neural network (NN) architecture by using a backpropagated Levenberg-Marquardt training (LMT) algorithm. NNs-LMT algorithm is a supervised machine learning for which the initial data set is generated by using MATLAB built in function known as "pdex4". Furthermore, the data set is validated by the processing of the NNs-LMT algorithm to find the approximate solutions for different scenarios and cases of mathematical model of micro-disk biosensors. Absolute errors, curve fitting, error histograms, regression and complexity analysis further validate the accuracy and robustness of the technique.

Indexed as

Biosensing TechniquesAlgorithmsBiocatalysisDiffusionEnzymes, ImmobilizedKineticsModels, BiologicalEnzymes, Immobilizedartificial neural networksenzymatic reactionLevenber–Marquardt trainingmathematical modelingMichaelis–Menten kineticsmicro-disk biosensorsoft computing

Identifiers

PMID34885892
PMCPMC8659114

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.