Mass Spectrometric Identification of Antimicrobial Peptides from Medicinal Seeds.

Tessa B Moyer, Amanda M Brechbill, Leslie M Hicks

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

0.7field-weighted citation impact, top 31% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

Plant stress and proteomics in medicinal plants.Frontiers in plant science · 2025
Review
Integration of high-throughput omics technologies in medicinal plant research: The new era of natural drug discovery.Frontiers in plant science · 2023
Review
Nutritional and Pharmaceutical Applications of Under-Explored Knottin Peptide-Rich Phytomedicines.Plants (Basel, Switzerland) · 2022
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tessa B MoyerDepartment of Chemistry, University of North Carolina at Chapel Hill, 125 South Road, Chapel Hill, NC 27599, USA.

Amanda M BrechbillDepartment of Chemistry, University of North Carolina at Chapel Hill, 125 South Road, Chapel Hill, NC 27599, USA.ORCID 0000-0002-9887-6902

Leslie M HicksDepartment of Chemistry, University of North Carolina at Chapel Hill, 125 South Road, Chapel Hill, NC 27599, USA.ORCID 0000-0002-8008-3998

University of North Carolina at Chapel Hill · US

Funding

American Chemical Society Division of Analytical Chemistry N/ANational Science Foundation CHE-1726291National Science Foundation DGE-1650016NIH HHS R01-GM125814

6 · The paper itself

Abstract

Traditional medicinal plants contain a variety of bioactive natural products including cysteine-rich (Cys-rich) antimicrobial peptides (AMPs). Cys-rich AMPs are often crosslinked by multiple disulfide bonds which increase their resistance to chemical and enzymatic degradation. However, this class of molecules is relatively underexplored. Herein, in silico analysis predicted 80-100 Cys-rich AMPs per species from three edible traditional medicinal plants:

Indexed as

Amino Acid SequenceAntimicrobial PeptidesFlaxMass SpectrometryModels, MolecularPlant ProteinsProteomicsSeedsSesamumTrifoliumAntimicrobial PeptidesPlant Proteinsantimicrobial peptidescysteine-richflaxLinum usitatissimumred cloversesameSesamum indicumTrifolium pratense

Identifiers

PMID34885884

DOI10.3390/molecules26237304

PMCPMC8659199

OpenAlexW3215598366

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.