ArticleMolecules (Basel, Switzerland)2021
Continuous Flow Synthesis of Propofol.
Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 21 citations in OpenAlex.
- Propofol emulsification in Intralipid and SMOFlipid: A promising alternative in response to future shortages.PloS one · 2025Article
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- Continuous-Flow Divergent Lithiation of 2,3-Dihalopyridines: Deprotolithiation versus Halogen Dance.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Scaled up and telescoped synthesis of propofol under continuous-flow conditions.Journal of flow chemistry · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Herein, we report a continuous flow process for the synthesis of 2,6-diisopropylphenol-also known as Propofol-a short-acting intravenous anesthesia, widely used in intensive care medicine to provide sedation and hypnosis. The synthesis is based on a two-step procedure: a double Friedel-Crafts alkylation followed by a decarboxylation step, both under continuous flow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.