Evidence map›Paper›PMID 34885728›Full record

ArticleMolecules (Basel, Switzerland)2021

Exploring Amantadine Derivatives as Urease Inhibitors: Molecular Docking and Structure-Activity Relationship (SAR) Studies.

Atteeque Ahmed, Aamer Saeed, Omar M Ali, Zeinhom M El-Bahy, Pervaiz Ali Channar, Asma Khurshid, Arfa Tehzeeb, Zaman Ashraf, Hussain Raza, Anwar Ul-Hamid and 1 more

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Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Atteeque AhmedDepartment of Chemistry, Quaid-I-Azam University, Islamabad 45320, Pakistan.
Aamer SaeedDepartment of Chemistry, Quaid-I-Azam University, Islamabad 45320, Pakistan.
Omar M AliDepartment of Chemistry, Turabah University College, Turabah Branch, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0002-2653-1542
Zeinhom M El-BahyDepartment of Chemistry, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, Egypt.
Pervaiz Ali ChannarDepartment of Chemistry, Quaid-I-Azam University, Islamabad 45320, Pakistan.
Asma KhurshidDepartment of Chemistry, Quaid-I-Azam University, Islamabad 45320, Pakistan.
Arfa TehzeebDepartment of Pharmacy, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Zaman AshrafDepartment of Chemistry, Allama Iqbal Open University, Islamabad 44000, Pakistan.ORCID 0000-0002-6620-9080
Hussain RazaDepartment of Biological Sciences, College of Natural Sciences, Kongju National University, 56 Gongjudehak-Ro, Gongju 314-701, Chungnam, Korea.ORCID 0000-0002-3078-6660
Anwar Ul-HamidCore Research Facilities, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia.ORCID 0000-0002-0259-301X
Mubashir HassanInstitute of Molecular Biology and Biotechnology, The University of Lahore, Lahore 54000, Pakistan.

Funding

Taif University TURSP-2020/81
6 · The paper itself

Abstract

This article describes the design and synthesis of a series of novel amantadine-thiourea conjugates (

Indexed as

Structure-Activity RelationshipAmantadineCatalytic DomainEnzyme InhibitorsHelicobacter InfectionsHelicobacter pyloriHumansHydrogen BondingKineticsMolecular Docking SimulationMolecular StructureThioureaUreaseAmantadineEnzyme InhibitorsThioureaUreaseacyl/aroyl thioureasenzyme inhibitory kineticsmolecular dockingsynthesisurease inhibitors

Identifiers

PMID34885728
PMCPMC8658948

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.