Evidence map›Paper›PMID 34885721›Full record

ArticleMolecules (Basel, Switzerland)2021

Towards an Improvement of Anticancer Activity of Benzyl Adenosine Analogs.

Verdiana Covelli, Manuela Grimaldi, Rosario Randino, Mohammad Firoznezhad, Maria Chiara Proto, Veronica De Simone, Gianluca Matteoli, Patrizia Gazzerro, Maurizio Bifulco, Anna Maria D'Ursi and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Biomolecules & biomedicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Verdiana CovelliDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132-84084 Fisciano, Italy.
Manuela GrimaldiDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132-84084 Fisciano, Italy.ORCID 0000-0001-7354-8008
Rosario RandinoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132-84084 Fisciano, Italy.
Mohammad FiroznezhadDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132-84084 Fisciano, Italy.ORCID 0000-0003-1201-7582
Maria Chiara ProtoDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132-84084 Fisciano, Italy.ORCID 0000-0002-7066-174X
Veronica De SimoneDepartment of Chronic Diseases, Metabolism and Ageing (CHROMETA)-Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Herestraat, 49-3000 Leuven, Belgium.ORCID 0000-0003-1934-3233
Gianluca MatteoliDepartment of Chronic Diseases, Metabolism and Ageing (CHROMETA)-Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Herestraat, 49-3000 Leuven, Belgium.
Patrizia GazzerroDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132-84084 Fisciano, Italy.ORCID 0000-0003-0576-2955
Maurizio BifulcoDepartment of Molecular, Medicine and Medical Biotechnology, University of Naples "Federico II", Via Pansini, 5-80131 Naples, Italy.
Anna Maria D'UrsiDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132-84084 Fisciano, Italy.
Manuela RodriquezDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132-84084 Fisciano, Italy.ORCID 0000-0002-4412-238X
University of Salerno · ITKU Leuven · BEUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

N6-Isopentenyladenosine (

Indexed as

AdenosineAnimalsAntineoplastic AgentsApoptosisCell ProliferationCell SurvivalColorectal NeoplasmsComputer SimulationDrug Screening Assays, AntitumorGeranyltranstransferaseHCT116 CellsHumansMevalonic AcidMiceStructure-Activity RelationshipUser-Computer InterfaceAdenosineAntineoplastic AgentsGeranyltranstransferaseMevalonic Acidcolorectal cancerFPPSN6-benzyladenosine derivatives

Identifiers

PMID34885721
PMCPMC8658949
OpenAlexW3216608735

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.