Evidence map›Paper›PMID 34885715›Full record

ReviewMolecules (Basel, Switzerland)2021

Antimicrobial Properties of Chitosan and Chitosan Derivatives in the Treatment of Enteric Infections.

Dazhong Yan, Yanzhen Li, Yinling Liu, Na Li, Xue Zhang, Chen Yan

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 171 papers.

0numbers the graph read from it
0cells of the map it votes in
171citing papers in PubMed
22.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

171 citing papers in PubMed, 493 citations in OpenAlex.

  1. Review
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  9. Freeze-Dried CS/PVP/PVA Composite Scaffolds Doped with Curcumin and SiOInternational journal of molecular sciences · 2026
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111 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dazhong YanThe Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Yanzhen LiThe Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Yinling LiuThe Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Na LiThe Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Xue ZhangThe Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.
Chen YanThe Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.ORCID 0000-0001-5803-3102
Affiliated Hospital of North Sichuan Medical College · CN

Funding

Science and Technology Department of Sichuan Province 14ZA0198
6 · The paper itself

Abstract

Antibiotics played an important role in controlling the development of enteric infection. However, the emergence of antibiotic resistance and gut dysbiosis led to a growing interest in the use of natural antimicrobial agents as alternatives for therapy and disinfection. Chitosan is a nontoxic natural antimicrobial polymer and is approved by GRAS (Generally Recognized as Safe by the United States Food and Drug Administration). Chitosan and chitosan derivatives can kill microbes by neutralizing negative charges on the microbial surface. Besides, chemical modifications give chitosan derivatives better water solubility and antimicrobial property. This review gives an overview of the preparation of chitosan, its derivatives, and the conjugates with other polymers and nanoparticles with better antimicrobial properties, explains the direct and indirect mechanisms of action of chitosan, and summarizes current treatment for enteric infections as well as the role of chitosan and chitosan derivatives in the antimicrobial agents in enteric infections. Finally, we suggested future directions for further research to improve the treatment of enteric infections and to develop more useful chitosan derivatives and conjugates.

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsBacterial InfectionsChitosanGastrointestinal DiseasesHumansNanoparticlesAnti-Bacterial AgentsAnti-Infective AgentsChitosanantibacterialantifungalantimicrobialantimicrobial mechanisms of chitosanchitosancolonization resistancedrug deliveryenteric infectiongut microbiota

Identifiers

PMID34885715
PMCPMC8659174
OpenAlexW3215655803

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.