Evidence map›Paper›PMID 34885432›Full record

ReviewMaterials (Basel, Switzerland)2021

Polymeric Micelles: A Promising Pathway for Dermal Drug Delivery.

Ana Parra, Ivana Jarak, Ana Santos, Francisco Veiga, Ana Figueiras

Abstract readReview
In one paragraph

Review in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Antiviral Activity ofBiomedicines · 2025
    Article
  6. Review
  7. Review
  8. Review
  9. Hydroxypropyl Cellulose Hydrogel ContainingGels (Basel, Switzerland) · 2024
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Nanoclays for wound management applications.Drug delivery and translational research · 2023
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ana ParraUniv. of Coimbra, Department of Pharmaceutical Technology, Faculty of Pharmacy, Azinhaga de Santa Comba, Pólo III-Pólo das Ciências da Saúde, 3000-548 Coimbra, Portugal.ORCID 0000-0001-7640-4595
Ivana JarakUniv. of Coimbra, Department of Pharmaceutical Technology, Faculty of Pharmacy, Azinhaga de Santa Comba, Pólo III-Pólo das Ciências da Saúde, 3000-548 Coimbra, Portugal.
Ana SantosUniv. of Coimbra, Department of Pharmaceutical Technology, Faculty of Pharmacy, Azinhaga de Santa Comba, Pólo III-Pólo das Ciências da Saúde, 3000-548 Coimbra, Portugal.
Francisco VeigaUniv. of Coimbra, Department of Pharmaceutical Technology, Faculty of Pharmacy, Azinhaga de Santa Comba, Pólo III-Pólo das Ciências da Saúde, 3000-548 Coimbra, Portugal.
Ana FigueirasUniv. of Coimbra, Department of Pharmaceutical Technology, Faculty of Pharmacy, Azinhaga de Santa Comba, Pólo III-Pólo das Ciências da Saúde, 3000-548 Coimbra, Portugal.ORCID 0000-0001-8170-1113

Funding

Fundação para a Ciência e Tecnologia PTDC/BTM-MAT/30255/2017 (POCI-01- 0145-FEDER-030255)Fundação para a Ciência e Tecnologia UIDB/50006/2020,
6 · The paper itself

Abstract

Nanotechnology is an area in great development and with application in the most varied fields of science, including cosmetic and pharmaceutical industries. Because conventional formulations for topical application are not always able to effectively penetrate the physical barrier that human skin exerts against factors and compounds of the external environment, polymeric micelles appear as alternative carriers for drugs and active ingredients delivery, also allowing ingredients with lower solubility and higher lipophilicity to be delivered. In fact, the augmented bioavailability of drugs, greater efficacy even at a lower dose, and selective drug delivery in specific organelles are very interesting advantages of the polymeric micelles usage in cutaneous application. As a consequence, they show a reduction in many of the local and systemic adverse effects, which might lead to an increase in patient compliance to the therapeutics, constituting a promising alternative to conventional topical formulations.

Indexed as

bioavailabilitycosmeticscutaneous applicationefficacynanotechnologypolymeric micellessafetyskinskin disease

Identifiers

PMID34885432
PMCPMC8658125

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.