Evidence map›Paper›PMID 34885364›Full record

ArticleMaterials (Basel, Switzerland)2021

Split Aptamers Immobilized on Polymer Brushes Integrated in a Lab-on-Chip System Based on an Array of Amorphous Silicon Photosensors: A Novel Sensor Assay.

Manasa Nandimandalam, Francesca Costantini, Nicola Lovecchio, Lorenzo Iannascoli, Augusto Nascetti, Giampiero de Cesare, Domenico Caputo, Cesare Manetti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Manasa NandimandalamDepartment of Environmental Biology, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
Francesca CostantiniDepartment of Environmental Biology, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0001-9576-8765
Nicola LovecchioDepartment of Information, Electronic and Telecommunication Engineering, Sapienza University of Rome, Via Eudossiana 18, 00184 Roma, Italy.ORCID 0000-0002-2571-2712
Lorenzo IannascoliDepartment of Information, Electronic and Telecommunication Engineering, Sapienza University of Rome, Via Eudossiana 18, 00184 Roma, Italy.ORCID 0000-0002-7471-2858
Augusto NascettiSchool of Aerospace Engineering, Sapienza University of Rome, Via Salaria 851/881, 00138 Rome, Italy.ORCID 0000-0001-8138-7494
Giampiero de CesareDepartment of Information, Electronic and Telecommunication Engineering, Sapienza University of Rome, Via Eudossiana 18, 00184 Roma, Italy.ORCID 0000-0002-9935-2975
Domenico CaputoDepartment of Information, Electronic and Telecommunication Engineering, Sapienza University of Rome, Via Eudossiana 18, 00184 Roma, Italy.ORCID 0000-0002-3709-6662
Cesare ManettiDepartment of Environmental Biology, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Innovative materials for the integration of aptamers in Lab-on-Chip systems are important for the development of miniaturized portable devices in the field of health-care and diagnostics. Herein we highlight a general method to tailor an aptamer sequence in two subunits that are randomly immobilized into a layer of polymer brushes grown on the internal surface of microfluidic channels, optically aligned with an array of amorphous silicon photosensors for the detection of fluorescence. Our approach relies on the use of split aptamer sequences maintaining their binding affinity to the target molecule. After binding the target molecule, the fragments, separately immobilized to the brush layer, form an assembled structure that in presence of a "light switching" complex [Ru(phen)

Indexed as

a-Si:H photosensorsATPLab-on-Chippolymer brushessplit aptamers

Identifiers

PMID34885364
PMCPMC8658169

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.