Evidence map›Paper›PMID 34885254›Full record

ArticleCancers2021

NS-11021 Modulates Cancer-Associated Processes Independently of BK Channels in Melanoma and Pancreatic Duct Adenocarcinoma Cell Lines.

Alessia Remigante, Paolo Zuccolini, Raffaella Barbieri, Loretta Ferrera, Rossana Morabito, Paola Gavazzo, Michael Pusch, Cristiana Picco

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Potential therapeutic targeting of BKMolecular oncology · 2026
    Review
  2. Article
  3. Peroxisome Deficiency in Cochlear Hair Cells Causes Hearing Loss by Deregulating BK Channels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Antioxidant Activity of Quercetin in a HInternational journal of molecular sciences · 2022
    Article
  9. Review
  10. Histamine activates an intracellular CaFrontiers in cell and developmental biology · 2022
    Article
  11. Review
  12. Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular CaFrontiers in cell and developmental biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Alessia RemiganteBiophysics Institute, National Research Council, 16149 Genoa, Italy.ORCID 0000-0001-9934-293X
Paolo ZuccoliniBiophysics Institute, National Research Council, 16149 Genoa, Italy.
Raffaella BarbieriBiophysics Institute, National Research Council, 16149 Genoa, Italy.
Loretta FerreraU.O.C. Genetica Medica, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Giannina Gaslini, 16147 Genoa, Italy.ORCID 0000-0003-0528-1158
Rossana MorabitoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.ORCID 0000-0003-4904-4963
Paola GavazzoBiophysics Institute, National Research Council, 16149 Genoa, Italy.
Michael PuschBiophysics Institute, National Research Council, 16149 Genoa, Italy.ORCID 0000-0002-8644-8847
Cristiana PiccoBiophysics Institute, National Research Council, 16149 Genoa, Italy.ORCID 0000-0002-6512-1802
Instituto di Biofisica · ESUniversity of Messina · ITIstituto Giannina Gaslini · IT

Funding

Italian Association for Cancer Research IG 21558Ministry of Education, Universities and Research PRIN 20174TB8KW
6 · The paper itself

Abstract

Potassium channels have emerged as regulators of carcinogenesis, thus introducing possible new therapeutic strategies in the fight against cancer. In particular, the large-conductance Ca

Indexed as

BK channelBK openerscalciumcancersIGR39 cellsPanc-1 cells

Identifiers

PMID34885254
PMCPMC8656804
OpenAlexW4200150356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.