Evidence map›Paper›PMID 34885236›Full record

ReviewCancers2021

A Network-Based Approach to Glioma Surgery: Insights from Functional Neurosurgery.

Nardin Samuel, Artur Vetkas, Aditya Pancholi, Can Sarica, Aaron Loh, Jurgen Germann, Irene E Harmsen, Jordy Tasserie, Vanessa Milano, Kazuaki Yamamoto and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Towards Optical Biopsy in Glioma Surgery.International journal of molecular sciences · 2025
    Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nardin SamuelDivision of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.
Artur VetkasDivision of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.
Aditya PancholiDivision of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.
Can SaricaDivision of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.ORCID 0000-0001-8419-7426
Aaron LohDivision of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.
Jurgen GermannDivision of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.ORCID 0000-0003-0995-8226
Irene E HarmsenDivision of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.
Jordy TasserieDivision of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.
Vanessa MilanoDivision of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.
Kazuaki YamamotoDivision of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.
Suneil K KaliaDivision of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.
Paul N KongkhamDivision of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.
Andres M LozanoDivision of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The evaluation and manipulation of structural and functional networks, which has been integral to advancing functional neurosurgery, is beginning to transcend classical subspecialty boundaries. Notably, its application in neuro-oncologic surgery has stimulated an exciting paradigm shift from the traditional localizationist approach, which is lacking in nuance and optimization. This manuscript reviews the existing literature and explores how structural and functional connectivity analyses have been leveraged to revolutionize and individualize pre-operative tumor evaluation and surgical planning. We describe how this novel approach may improve cognitive and neurologic preservation after surgery and attenuate tumor spread. Furthermore, we demonstrate how connectivity analysis combined with neuromodulation techniques can be employed to induce post-operative neuroplasticity and personalize neurorehabilitation. While the landscape of functional neuro-oncology is still evolving and requires further study to encourage more widespread adoption, this functional approach can transform the practice of neuro-oncologic surgery and improve the care and outcomes of patients with intra-axial tumors.

Indexed as

connectivityfunctional neurosurgerygliomanetworksneuroplasticity

Identifiers

PMID34885236
PMCPMC8656669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.