Evidence map›Paper›PMID 34885229›Full record

ReviewCancers2021

Novel Therapeutic Strategies for Refractory Ovarian Cancers: Clear Cell and Mucinous Carcinomas.

Tadahiro Shoji, Shunsuke Tatsuki, Marina Abe, Hidetoshi Tomabechi, Eriko Takatori, Yoshitaka Kaido, Takayuki Nagasawa, Masahiro Kagabu, Tsukasa Baba, Hiroaki Itamochi

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Tadahiro ShojiDepartment of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Iwate 028-3695, Japan.ORCID 0000-0002-9022-3333
Shunsuke TatsukiDepartment of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Iwate 028-3695, Japan.
Marina AbeDepartment of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Iwate 028-3695, Japan.
Hidetoshi TomabechiDepartment of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Iwate 028-3695, Japan.
Eriko TakatoriDepartment of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Iwate 028-3695, Japan.
Yoshitaka KaidoDepartment of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Iwate 028-3695, Japan.
Takayuki NagasawaDepartment of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Iwate 028-3695, Japan.
Masahiro KagabuDepartment of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Iwate 028-3695, Japan.ORCID 0000-0003-0926-1015
Tsukasa BabaDepartment of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Iwate 028-3695, Japan.
Hiroaki ItamochiDepartment of Clinical Oncology, Iwate Medical University School of Medicine, Iwate 028-3695, Japan.
Iwate Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer has the worst prognosis among gynecological cancers. In particular, clear cell and mucinous carcinomas are less sensitive to chemotherapy. The establishment of new therapies is necessary to improve the treatment outcomes for these carcinomas. In previous clinical studies, chemotherapy with cytotoxic anticancer drugs has failed to demonstrate better treatment outcomes than paclitaxel + carboplatin therapy. In recent years, attention has been focused on treatment with molecular target drugs and immune checkpoint inhibitors that target newly identified biomarkers. The issues that need to be addressed include the most appropriate combination of therapies, identifying patients who may benefit from each therapy, and how results should be incorporated into the standard of care for ovarian clear cell and mucinous carcinomas. In this article, we have reviewed the most promising therapies for ovarian clear cell and mucinous carcinomas, which are regarded as intractable, with an emphasis on therapies currently being investigated in clinical studies.

Indexed as

chemotherapyclear cell carcinomaclinical trialmucinous carcinomaovarian cancer

Identifiers

PMID34885229
PMCPMC8656608
OpenAlexW4200256195

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.