Evidence map›Paper›PMID 34885222›Full record

ArticleCancers2021

Object Detection Improves Tumour Segmentation in MR Images of Rare Brain Tumours.

Hamza Chegraoui, Cathy Philippe, Volodia Dangouloff-Ros, Antoine Grigis, Raphael Calmon, Nathalie Boddaert, Frédérique Frouin, Jacques Grill, Vincent Frouin

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Hamza ChegraouiUniversité Paris-Saclay, Neurospin, CEA, 91191 Gif-sur-Yvette, France.
Cathy PhilippeUniversité Paris-Saclay, Neurospin, CEA, 91191 Gif-sur-Yvette, France.ORCID 0000-0002-3262-4390
Volodia Dangouloff-RosPediatric Radiology Department, Hôpital Necker Enfants Malades, APHP, IMAGINE Institute, Inserm, Université de Paris, 75015 Paris, France.ORCID 0000-0003-1260-5886
Antoine GrigisUniversité Paris-Saclay, Neurospin, CEA, 91191 Gif-sur-Yvette, France.
Raphael CalmonPediatric Radiology Department, Hôpital Necker Enfants Malades, APHP, IMAGINE Institute, Inserm, Université de Paris, 75015 Paris, France.
Nathalie BoddaertPediatric Radiology Department, Hôpital Necker Enfants Malades, APHP, IMAGINE Institute, Inserm, Université de Paris, 75015 Paris, France.
Frédérique FrouinLITO U1288, Inserm-Institut Curie, 91400 Orsay, France.ORCID 0000-0002-7288-1543
Jacques GrillDepartment of Pediatric and Adolescent Oncology, Gustave Roussy, Inserm U981, Université Paris-Saclay, 94800 Villejuif, France.
Vincent FrouinUniversité Paris-Saclay, Neurospin, CEA, 91191 Gif-sur-Yvette, France.ORCID 0000-0001-9360-6623
Commissariat à l'Énergie Atomique et aux Énergies Alternatives · FRHôpital Necker-Enfants Malades · FRInserm · FR

Funding

IDRIS GENCI 537 2021-AD011011977Imagine for Margo, France BiomedeIA
6 · The paper itself

Abstract

Tumour lesion segmentation is a key step to study and characterise cancer from MR neuroradiological images. Presently, numerous deep learning segmentation architectures have been shown to perform well on the specific tumour type they are trained on (e.g., glioblastoma in brain hemispheres). However, a high performing network heavily trained on a given tumour type may perform poorly on a rare tumour type for which no labelled cases allows training or transfer learning. Yet, because some visual similarities exist nevertheless between common and rare tumours, in the lesion and around it, one may split the problem into two steps: object detection and segmentation. For each step, trained networks on common lesions could be used on rare ones following a domain adaptation scheme without extra fine-tuning. This work proposes a resilient tumour lesion delineation strategy, based on the combination of established elementary networks that achieve detection and segmentation. Our strategy allowed us to achieve robust segmentation inference on a rare tumour located in an unseen tumour context region during training. As an example of a rare tumour, Diffuse Intrinsic Pontine Glioma (DIPG), we achieve an average dice score of 0.62 without further training or network architecture adaptation.

Indexed as

brain tumourdeep learningDIPGdomain adaptationobject-detectionsegmentation

Identifiers

PMID34885222
PMCPMC8657375
OpenAlexW4200321436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.