Evidence map›Paper›PMID 34885183›Full record

ArticleCancers2021

Factors Predicting Pathological Response to Neoadjuvant Chemoradiotherapy in Rectal Cancer: The Experience of a Single Institution with 269 Patients (STONE-01).

Michele Fiore, Pasquale Trecca, Luca E Trodella, Roberto Coppola, Marco Caricato, Damiano Caputo, Alessandro Coppola, Gian M Petrianni, Gabriele D'Ercole, Edy Ippolito and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Michele FioreDepartment of Radiation Oncology, Campus Bio-Medico University, 00128 Rome, Italy.ORCID 0000-0003-1889-4578
Pasquale TreccaDepartment of Radiation Oncology, Campus Bio-Medico University, 00128 Rome, Italy.ORCID 0000-0001-9365-9741
Luca E TrodellaDepartment of Radiation Oncology, Campus Bio-Medico University, 00128 Rome, Italy.
Roberto CoppolaDepartment of General Surgery, Campus Bio-Medico University, 00128 Rome, Italy.ORCID 0000-0001-5798-0714
Marco CaricatoDepartment of Colorectal Surgery, Campus Bio-Medico University, 00128 Rome, Italy.ORCID 0000-0002-5610-1615
Damiano CaputoDepartment of General Surgery, Campus Bio-Medico University, 00128 Rome, Italy.ORCID 0000-0001-7058-1945
Alessandro CoppolaDepartment of General Surgery, Campus Bio-Medico University, 00128 Rome, Italy.ORCID 0000-0002-5550-1756
Gian M PetrianniDepartment of Radiation Oncology, Campus Bio-Medico University, 00128 Rome, Italy.
Gabriele D'ErcoleDepartment of Radiation Oncology, Campus Bio-Medico University, 00128 Rome, Italy.ORCID 0000-0002-5796-7525
Edy IppolitoDepartment of Radiation Oncology, Campus Bio-Medico University, 00128 Rome, Italy.
Rolando M D'AngelilloDepartment of Radiation Oncology, University "Tor Vergata", 00133 Rome, Italy.
Sara RamellaDepartment of Radiation Oncology, Campus Bio-Medico University, 00128 Rome, Italy.ORCID 0000-0002-5782-7717
Università Campus Bio-Medico · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe aim of this study was to define a potential benefit of pathological complete response rate (pCR) and downstaging rate after neoadjuvant chemoradiotherapy (CRT) in relation to treatment and patient factors in locally advanced rectal cancer.

methodsWe performed a retrospective cohort study. Patients were divided according to chemotherapy regimens concurrent to radiotherapy (1-drug vs. 2-drug) and according to the time interval between the end of CRT and surgery (≤8 weeks vs. >8 weeks), as well as in relation to specific relevant clinical factors. Logistic regression was used to estimate the independent factors for pCR and downstaging.

results269 patients were eligible for this study. Overall, pCR and downstaging rates were 26% and 75.4%, respectively. Univariate analysis showed that female gender (

conclusionsThis study indicates that, in our population, an interval time to surgery of >8 weeks is an independent significant factor for pCR and downstaging. Further prospective studies are needed to define the best interval time.

Indexed as

chemoradiationpredictive factorsrectal cancerresponse

Identifiers

PMID34885183
PMCPMC8657113
OpenAlexW3217531897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.