Evidence map›Paper›PMID 34885181›Full record

ArticleCancers2021

EWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro Model.

Margit Bleijs, Corine Pleijte, Sem Engels, Femke Ringnalda, Friederike Meyer-Wentrup, Marc van de Wetering, Hans Clevers

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Desmoplastic small round cell tumor: an update of current management practices.Journal of the Egyptian National Cancer Institute · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. MERTK Inhibition as a Targeted Novel Cancer Therapy.International journal of molecular sciences · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Small round cell sarcomas.Nature reviews. Disease primers · 2022
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Margit BleijsPrincess Máxima Center for Pediatric Oncology, 3584 CT Utrecht, The Netherlands.
Corine PleijtePrincess Máxima Center for Pediatric Oncology, 3584 CT Utrecht, The Netherlands.
Sem EngelsPrincess Máxima Center for Pediatric Oncology, 3584 CT Utrecht, The Netherlands.
Femke RingnaldaPrincess Máxima Center for Pediatric Oncology, 3584 CT Utrecht, The Netherlands.
Friederike Meyer-WentrupPrincess Máxima Center for Pediatric Oncology, 3584 CT Utrecht, The Netherlands.
Marc van de WeteringPrincess Máxima Center for Pediatric Oncology, 3584 CT Utrecht, The Netherlands.ORCID 0000-0002-8195-9939
Hans CleversPrincess Máxima Center for Pediatric Oncology, 3584 CT Utrecht, The Netherlands.
Oncode Institute · NLPrincess Máxima Center · NLRoyal Netherlands Academy of Arts and Sciences · NL

Funding

Foundation KiKa 262
6 · The paper itself

Abstract

Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive soft tissue sarcoma with a lack of effective treatment options and a poor prognosis. DSRCT is characterized by a chromosomal translocation, resulting in the

Indexed as

DSRCTEWSR1-WT1in vitro modelpediatric cancerpreclinical modelsarcoma

Identifiers

PMID34885181
PMCPMC8657306
OpenAlexW4200460468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.