Evidence map›Paper›PMID 34885139›Full record

ArticleCancers2021

Epigenetic Dysregulation of

David A Skaar, Eric C Dietze, Jackelyn A Alva-Ornelas, David Ann, Dustin E Schones, Terry Hyslop, Christopher Sistrunk, Carola Zalles, Adrian Ambrose, Kendall Kennedy and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. The Mechanism of DNA Methylation and miRNA in Breast Cancer.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

David A SkaarDepartment of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.ORCID 0000-0003-3530-957X
Eric C DietzeBeckman Research Institute, Department of Population Sciences, City of Hope, Duarte, CA 91010, USA.
Jackelyn A Alva-OrnelasBeckman Research Institute, Department of Population Sciences, City of Hope, Duarte, CA 91010, USA.
David AnnBeckman Research Institute, Department of Population Sciences, City of Hope, Duarte, CA 91010, USA.
Dustin E SchonesBeckman Research Institute, Department of Population Sciences, City of Hope, Duarte, CA 91010, USA.
Terry HyslopDepartment of Biostatistics, School of Medicine, Duke University, Durham, NC 27710, USA.
Christopher SistrunkBeckman Research Institute, Department of Population Sciences, City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-5951-1361
Carola ZallesDepartment of Pathology, Mercy Hospital, Miami, FL 33133, USA.
Adrian AmbroseBeckman Research Institute, Department of Population Sciences, City of Hope, Duarte, CA 91010, USA.
Kendall KennedyBeckman Research Institute, Department of Population Sciences, City of Hope, Duarte, CA 91010, USA.
Ombeni IdassiBeckman Research Institute, Department of Population Sciences, City of Hope, Duarte, CA 91010, USA.
Gustavo Miranda CarboniLaboratory of Oncology, Department of Oncology, School of Medicine, University of Tennessee Health Science, Memphis, TN 38163, USA.
Michael N GouldMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI 53706, USA.
Randy L JirtleDepartment of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.ORCID 0000-0003-1767-045X
Victoria L SeewaldtBeckman Research Institute, Department of Population Sciences, City of Hope, Duarte, CA 91010, USA.
City of Hope · USNorth Carolina State University · USDuke University · USMercy Hospital · USUniversity of Tennessee Health Science Center · USUniversity of Wisconsin–Madison · US

Funding

Project 2U54CA285116 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Victoria L. Seewaldt · 2023 to 2026
$6.8M
Diversity Supplement to Combined Breast MRI/Biomarker Strategies to Identify Aggressive BiologyU01CA189283 · NCI · DUKE UNIVERSITY · PI CLINTON, STEVEN K, MIRANDA-CARBONI, GUSTAVO ADOLFO · 2015 to 2020
$4.0M
Tension-Stat3-miR-mediated metastasisR01CA192914 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEEWALDT, VICTORIA L., WEAVER, VALERIE MARIE · 2015 to 2019
$2.9M
Mechanisms of breast cancer associated with obesityR01CA170851 · NCI · TUFTS UNIVERSITY BOSTON · PI KUPERWASSER, CHARLOTTE, SEEWALDT, VICTORIA L. · 2012 to 2015
$2.6M
2/2 Drug Development and Capacity Building: A UCR/CoH-CCC Partnership (Pilot Project 2)P20CA242620 · NCI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI MARTINEZ, ERNEST · 2019 to 2022
$1.2M
Project 2P20CA242619 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SEEWALDT, VICTORIA L. · 2019 to 2022
$937k
NCI NIH HHS P20 CA242619NCI NIH HHS P20 CA242620NCI NIH HHS R01 CA170851NCI NIH HHS R01 CA192914NCI NIH HHS U54 CA285116
6 · The paper itself

Abstract

Genomic imprinting is an inherited form of parent-of-origin specific epigenetic gene regulation that is dysregulated by poor prenatal nutrition and environmental toxins.

Indexed as

epigeneticsimprintingKCNK9triple negative breast cancer

Identifiers

PMID34885139
PMCPMC8656495
OpenAlexW3216463961

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.