Evidence map›Paper›PMID 34885098›Full record

ArticleCancers2021

Stage I-IV Colorectal Cancer Prognosis Can Be Predicted by Type and Number of Intratumoral Macrophages and CLEVER-1

Annika Ålgars, Lotta Kemppinen, Ruth Fair-Mäkelä, Harri Mustonen, Caj Haglund, Sirpa Jalkanen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Annika ÅlgarsDepartment of Oncology, Turku University Hospital, 20521 Turku, Finland.
Lotta KemppinenMediCity Research Laboratory and InFLAMES Flagship, Department of Microbiology and Immunology, University of Turku, 20520 Turku, Finland.
Ruth Fair-MäkeläInstitute of Biomedicine, University of Turku, 20520 Turku, Finland.ORCID 0000-0003-2803-9890
Harri MustonenDepartment of Surgery, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4, 00029 Helsinki, Finland.
Caj HaglundDepartment of Surgery, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4, 00029 Helsinki, Finland.
Sirpa JalkanenMediCity Research Laboratory and InFLAMES Flagship, Department of Microbiology and Immunology, University of Turku, 20520 Turku, Finland.
University of Turku · FIUniversity of Helsinki · FI

Funding

The Finnish Academy N/AThe Finnish Cancer Foundation N/AThe Sigrid Juselius Foundation N/A
6 · The paper itself

Abstract

Macrophages, which are key players in the tumor microenvironment and affect the prognosis of many cancers, interact with lymphatic vessels in tumor tissue. However, the prognostic role of tumor-associated macrophages (TAM) and lymphatic vessels in human colorectal cancer (CRC) remains controversial. We investigated the prognostic role of CD68

Indexed as

CD68CLEVER-1colorectal cancerlymphatic vesselmacrophagesurvival

Identifiers

PMID34885098
PMCPMC8656733
OpenAlexW3217514848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.