ReviewCancers2021
Primary Skull Base Chondrosarcomas: A Systematic Review.
Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Radiotherapy of orbital metastases: a systematic review of management and treatment outcomes on behalf of palliative care study group of Italian association of radiotherapy and clinical oncology (AIRO).The British journal of radiology · 2023Pooled it
- Surgical Management of Craniovertebral Junction Schwannomas: A Systematic Review.Current oncology (Toronto, Ont.) · 2022Pooled it
- Endocrine disorders after primary gamma knife radiosurgery for pituitary adenomas: A systematic review and meta-analysis.Pituitary · 2022Pooled it
- Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, and Survival Outcomes.World neurosurgery · 2022Pooled it
- Delayed Diagnosis and Multimodality Management of a Primary Myxoid Chondrosarcoma of the Skull Base: A Case Report.Cureus · 2026Article
- Endoscopic transsphenoidal resection of large sellar chondrosarcoma compressing the optic nerve: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- A multicorridor strategy including the infralabyrinthine route for extensive skull base chondrosarcoma: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Sinonasal Sarcomas Management: An International Consensus Statement.International forum of allergy & rhinology · 2026Article
- Article
- Longitudinal Quality-of-Life Outcomes of Skull Base Chondrosarcoma Patients following Surgical Resection.Journal of neurological surgery. Part B, Skull base · 2025Article
- Review of imaging modalities and radiological findings of calvarial lesions.World journal of radiology · 2025Review
- Maxillary Mesenchymal Chondrosarcoma Affecting A Pediatric Patient: Case Report Showing Long-Term Follow-Up and Detailed Literature Review.Journal of maxillofacial and oral surgery · 2025Article
- Alternative lengthening of telomeres confers favorable prognosis in chondrosarcomas.Journal of translational medicine · 2025Article
- UK guidelines for the management of bone sarcomas.British journal of cancer · 2025Review
- Surgical management of chondrosarcomas of the skull-base and temporal bone.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Complete excision of a giant chondrosarcoma within the cavernous sinus: a case report and literature review.BMC neurology · 2024Review
- Article
- Advancing the Management of Skull Base Chondrosarcomas: A Systematic Review of Targeted Therapies.Journal of personalized medicine · 2024Review
- Skull-Base Chondrosarcoma: A Systematic Review of the Role of Postoperative Radiotherapy.Cancers · 2024Review
- Surgical management of skull base chordomas and chondrosarcomas: insights from a national cohort study.BMJ oncology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 9 institutions in 5 countries.
Funding
Abstract
backgroundPrimary skull base chondrosarcomas (SBCs) can severely affect patients' quality of life. Surgical-resection and radiotherapy are feasible but may cause debilitating complications. We systematically reviewed the literature on primary SBCs.
methodsPubMed, EMBASE, Scopus, Web-of-Science, and Cochrane were searched following the PRISMA guidelines to include studies of patients with primary SBCs. Clinical characteristics, management strategies, and treatment outcomes were analyzed.
resultsWe included 33 studies comprising 1307 patients. Primary SBCs mostly involved the middle-fossa (72.7%), infiltrating the cavernous-sinus in 42.4% of patients. Cranial-neuropathies were reported in 810 patients (62%). Surgical-resection (93.3%) was preferred over biopsy (6.6%). The most frequent open surgical approaches were frontotemporal-orbitozygomatic (17.6%) and pterional (11.9%), and 111 patients (21.3%) underwent endoscopic-endonasal resection. Post-surgical cerebrospinal-fluid leaks occurred in 36 patients (6.5%). Radiotherapy was delivered in 1018 patients (77.9%): photon-based (41.4%), proton-based (64.2%), and carbon-based (13.1%). Severe post-radiotherapy complications, mostly hypopituitarism (15.4%) and hearing loss (7.1%) were experienced by 251 patients (30.7%). Post-treatment symptom-improvement (46.7%) and reduced/stable tumor volumes (85.4%) showed no differences based on radiotherapy-protocols (
conclusionSurgical-resection and radiotherapy are effective treatments in primary SBCs, with acceptable complication rates and favorable local tumor control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.