Evidence map›Paper›PMID 34885053›Full record

ArticleCancers2021

MEOX2 Transcription Factor Is Involved in Survival and Adhesion of Glioma Stem-like Cells.

Gaëlle Tachon, Konstantin Masliantsev, Pierre Rivet, Amandine Desette, Serge Milin, Elise Gueret, Michel Wager, Lucie Karayan-Tapon, Pierre-Olivier Guichet

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
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  6. Article
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  9. C-Fos-activated circRPPH1 contributes to glioma stemness.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Gaëlle TachonUniversité de Poitiers, CHU Poitiers, ProDiCeT, 86000 Poitiers, France.ORCID 0000-0002-0391-7143
Konstantin MasliantsevUniversité de Poitiers, CHU Poitiers, ProDiCeT, 86000 Poitiers, France.ORCID 0000-0003-1250-8402
Pierre RivetLaboratoire de Cancérologie Biologique, CHU Poitiers, 86000 Poitiers, France.
Amandine DesetteUniversité de Poitiers, CHU Poitiers, ProDiCeT, 86000 Poitiers, France.ORCID 0000-0001-7504-4081
Serge MilinService d'Anatomo-Cytopathologie, CHU Poitiers, 86000 Poitiers, France.
Elise GueretUniversité Montpellier, CNRS, INSERM, 34094 Montpellier, France.ORCID 0000-0003-0714-3197
Michel WagerUniversité de Poitiers, CHU Poitiers, ProDiCeT, 86000 Poitiers, France.
Lucie Karayan-TaponUniversité de Poitiers, CHU Poitiers, ProDiCeT, 86000 Poitiers, France.
Pierre-Olivier GuichetUniversité de Poitiers, CHU Poitiers, ProDiCeT, 86000 Poitiers, France.ORCID 0000-0003-0115-2199
Université de Poitiers · FRCentre Hospitalier Universitaire de Poitiers · FRCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The high expression of MEOX2 transcription factor is closely associated with poor overall survival in glioma. MEOX2 has recently been described as an interesting prognostic biomarker, especially for lower grade glioma. MEOX2 has never been studied in glioma stem-like cells (GSC), responsible for glioma recurrence. The aim of our study was to investigate the role of MEOX2 in GSC. Loss of function approach using siRNA was used to assess the impact of MEOX2 on GSC viability and stemness phenotype. MEOX2 was localized in the nucleus and its expression was heterogeneous between GSCs. MEOX2 expression depends on the methylation state of its promoter and is strongly associated with

Indexed as

CDH10differentiationERKglioma stem-like cellsMEOX2

Identifiers

PMID34885053
PMCPMC8672280
OpenAlexW3215967055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.