Evidence map›Paper›PMID 34884976›Full record

ArticleInternational journal of molecular sciences2021

Azobenzene/Tetraethyl Ammonium Photochromic Potassium Channel Blockers: Scope and Limitations for Design of Para-Substituted Derivatives with Specific Absorption Band Maxima and Thermal Isomerization Rate.

Daniil M Strashkov, Vladimir N Mironov, Dmitrii M Nikolaev, Maxim S Panov, Stanislav A Linnik, Andrey S Mereshchenko, Vladimir A Kochemirovsky, Andrey V Vasin, Mikhail N Ryazantsev

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniil M StrashkovInstitute of Biomedical Systems and Biotechnologies, Peter the Great St. Petersburg Polytechnic University, 29 Polytechnicheskaya Str., 195251 St. Petersburg, Russia.
Vladimir N MironovNanotechnology Research and Education Centre RAS, Saint Petersburg Academic University, 8/3 Khlopina Street, 194021 St. Petersburg, Russia.
Dmitrii M NikolaevInstitute of Biomedical Systems and Biotechnologies, Peter the Great St. Petersburg Polytechnic University, 29 Polytechnicheskaya Str., 195251 St. Petersburg, Russia.
Maxim S PanovInstitute of Chemistry, Saint Petersburg State University, 7/9 Universitetskaya nab., 199034 St. Petersburg, Russia.
Stanislav A LinnikInstitute of Biomedical Systems and Biotechnologies, Peter the Great St. Petersburg Polytechnic University, 29 Polytechnicheskaya Str., 195251 St. Petersburg, Russia.
Andrey S MereshchenkoInstitute of Chemistry, Saint Petersburg State University, 7/9 Universitetskaya nab., 199034 St. Petersburg, Russia.ORCID 0000-0001-9390-1446
Vladimir A KochemirovskyInstitute of Biomedical Systems and Biotechnologies, Peter the Great St. Petersburg Polytechnic University, 29 Polytechnicheskaya Str., 195251 St. Petersburg, Russia.ORCID 0000-0002-0352-3793
Andrey V VasinInstitute of Biomedical Systems and Biotechnologies, Peter the Great St. Petersburg Polytechnic University, 29 Polytechnicheskaya Str., 195251 St. Petersburg, Russia.ORCID 0000-0002-1391-7139
Mikhail N RyazantsevInstitute of Chemistry, Saint Petersburg State University, 7/9 Universitetskaya nab., 199034 St. Petersburg, Russia.ORCID 0000-0003-3413-1706

Funding

The Ministry of Science and Higher Education of the Russian Federation as part of World-class Research Center program: Advanced Digital Technologies contract No. 075-15-2020-934 dated by 17.11.2020
6 · The paper itself

Abstract

Azobenzene/tetraethyl ammonium photochromic ligands (ATPLs) are photoactive compounds with a large variety of photopharmacological applications such as nociception control or vision restoration. Absorption band maximum and lifetime of the less stable isomer are important characteristics that determine the applicability of ATPLs. Substituents allow to adjust these characteristics in a range limited by the azobenzene/tetraethyl ammonium scaffold. The aim of the current study is to find the scope and limitations for the design of ATPLs with specific spectral and kinetic properties by introducing para substituents with different electronic effects. To perform this task we synthesized ATPLs with various electron acceptor and electron donor functional groups and studied their spectral and kinetic properties using flash photolysis and conventional spectroscopy techniques as well as quantum chemical modeling. As a result, we obtained diagrams that describe correlations between spectral and kinetic properties of ATPLs (absorption maxima of

Indexed as

Quantum TheoryThermodynamicsAzo CompoundsChemical PhenomenaKineticsPotassium Channel BlockersStereoisomerismTetraethylammoniumazobenzeneAzo CompoundsPotassium Channel BlockersTetraethylammoniumazobenzeneazobenzene thermal isomerization rateDENAQphotochromic ion channel blockersphotopharmacologyred-shifting azobenzenesspectral tuning of azobenzene photoswitches

Identifiers

PMID34884976
PMCPMC8658355

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.