Evidence map›Paper›PMID 34884911›Full record

ArticleInternational journal of molecular sciences2021

Long-Term Effects of Neural Precursor Cell Transplantation on Secondary Injury Processes and Functional Recovery after Severe Cervical Contusion-Compression Spinal Cord Injury.

Alexander Younsi, Guoli Zheng, Lennart Riemann, Moritz Scherer, Hao Zhang, Mohamed Tail, Maryam Hatami, Thomas Skutella, Andreas Unterberg, Klaus Zweckberger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  9. Spinal cord injury: molecular mechanisms and therapeutic interventions.Signal transduction and targeted therapy · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Alexander YounsiDepartment of Neurosurgery, University Hospital Heidelberg, University of Heidelberg, INF 400, 69120 Heidelberg, Germany.ORCID 0000-0002-8218-9243
Guoli ZhengDepartment of Neurosurgery, University Hospital Heidelberg, University of Heidelberg, INF 400, 69120 Heidelberg, Germany.
Lennart RiemannDepartment of Neurosurgery, University Hospital Heidelberg, University of Heidelberg, INF 400, 69120 Heidelberg, Germany.
Moritz SchererDepartment of Neurosurgery, University Hospital Heidelberg, University of Heidelberg, INF 400, 69120 Heidelberg, Germany.
Hao ZhangDepartment of Neurosurgery, University Hospital Heidelberg, University of Heidelberg, INF 400, 69120 Heidelberg, Germany.
Mohamed TailDepartment of Neurosurgery, University Hospital Heidelberg, University of Heidelberg, INF 400, 69120 Heidelberg, Germany.
Maryam HatamiDepartment of Neuroanatomy, Institute for Anatomy and Cell Biology, University of Heidelberg, INF 307, 69120 Heidelberg, Germany.
Thomas SkutellaDepartment of Neuroanatomy, Institute for Anatomy and Cell Biology, University of Heidelberg, INF 307, 69120 Heidelberg, Germany.
Andreas UnterbergDepartment of Neurosurgery, University Hospital Heidelberg, University of Heidelberg, INF 400, 69120 Heidelberg, Germany.
Klaus ZweckbergerDepartment of Neurosurgery, University Hospital Heidelberg, University of Heidelberg, INF 400, 69120 Heidelberg, Germany.
Heidelberg University · DE

Funding

Cervical Spine Research Society NAINBC Innovation Fund of the University of Heidelberg NA
6 · The paper itself

Abstract

Cervical spinal cord injury (SCI) remains a devastating event without adequate treatment options despite decades of research. In this context, the usefulness of common preclinical SCI models has been criticized. We, therefore, aimed to use a clinically relevant animal model of severe cervical SCI to assess the long-term effects of neural precursor cell (NPC) transplantation on secondary injury processes and functional recovery. To this end, we performed a clip contusion-compression injury at the C6 level in 40 female Wistar rats and a sham surgery in 10 female Wistar rats. NPCs, isolated from the subventricular zone of green fluorescent protein (GFP) expressing transgenic rat embryos, were transplanted ten days after the injury. Functional recovery was assessed weekly, and FluoroGold (FG) retrograde fiber-labeling, as well as manganese-enhanced magnetic resonance imaging (MEMRI), were performed prior to the sacrifice of the animals eight weeks after SCI. After cryosectioning of the spinal cords, immunofluorescence staining was conducted. Results were compared between the treatment groups (NPC, Vehicle, Sham) and statistically analyzed (

Indexed as

AnimalsCell DifferentiationCells, CulturedCervical VertebraeDisease Models, AnimalFemaleGait AnalysisGreen Fluorescent ProteinsMagnetic Resonance ImagingMotor NeuronsNeural Stem CellsOligodendrogliaRatsRats, TransgenicRats, WistarRecovery of FunctionGreen Fluorescent Proteinsfunctional recoveryneuronal precursor cellsneuroregenerationNPCsSCIspinal cord injurystem cell therapy

Identifiers

PMID34884911
PMCPMC8658203
OpenAlexW4200294498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.