Evidence map›Paper›PMID 34884896›Full record

ArticleInternational journal of molecular sciences2021

Docosahexaenoic Acid Modulates Paracellular Absorption of Testosterone and Claudin-1 Expression in a Tissue-Engineered Skin Model.

Andréa Tremblay, Mélissa Simard, Sophie Morin, Roxane Pouliot

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Andréa TremblayCentre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Québec, QC G1J 1Z4, Canada.
Mélissa SimardCentre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Québec, QC G1J 1Z4, Canada.ORCID 0000-0001-6945-9619
Sophie MorinCentre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Québec, QC G1J 1Z4, Canada.
Roxane PouliotCentre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Québec, QC G1J 1Z4, Canada.ORCID 0000-0002-2423-9599
Université Laval · CA

Funding

Natural Sciences and Engineering Research Council RGPIN-2019-05610
6 · The paper itself

Abstract

Healthy skin moLEdels produced by tissue-engineering often present a suboptimal skin barrier function as compared with normal human skin. Moreover, skin substitutes reconstructed according to the self-assembly method were found to be deficient in polyunsaturated fatty acids (PUFAs). Therefore, in this study, we investigated the effects of a supplementation of the culture media with docosahexaenoic acid (DHA) on the barrier function of skin substitutes. To this end, 10 μM DHA-supplemented skin substitutes were produced (

Indexed as

AdolescentCells, CulturedChromatography, GasClaudin-1Docosahexaenoic AcidsFemaleGene Expression RegulationHumansKeratinocytesLipid MetabolismMiddle AgedPermeabilitySkinSkin, ArtificialTestosteroneTight Junction ProteinsClaudin-1Docosahexaenoic AcidsTestosteroneTight Junction Proteinsdocosahexaenoic acidlipidomicspolyunsaturated fatty acidsskin barrier functionskin substitutestight junctionstissue engineering

Identifiers

PMID34884896
PMCPMC8658185
OpenAlexW4200120492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.