Evidence map›Paper›PMID 34884894›Full record

ArticleInternational journal of molecular sciences2021

Validation of a Lab-on-Chip Assay for Measuring Sorafenib Effectiveness on HCC Cell Proliferation.

Emanuele Piccinno, Anna Grazia Monteduro, Francesco Dituri, Silvia Rizzato, Gianluigi Giannelli, Giuseppe Maruccio

Abstract readValidation Study
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  5. Article
  6. Detection ofBiosensors · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emanuele Piccinno *1. National Institute of Gastroenterology “Saverio de Bellis”, IRCCS Research Hospital, Castellana Grotte, 70013 Bari, ItalyORCID 0000-0002-7988-1917
Anna Grazia Monteduro *Omnics Research Group, Department of Mathematics and Physics "Ennio De Giorgi", Institute of Nanotechnology CNR-Nanotec and INFN Sezione di Lecce, University of Salento, Via per Monteroni, 73100 Lecce, Italy.ORCID 0000-0002-9265-134X
Francesco Dituri1. National Institute of Gastroenterology “Saverio de Bellis”, IRCCS Research Hospital, Castellana Grotte, 70013 Bari, Italy
Silvia RizzatoOmnics Research Group, Department of Mathematics and Physics "Ennio De Giorgi", Institute of Nanotechnology CNR-Nanotec and INFN Sezione di Lecce, University of Salento, Via per Monteroni, 73100 Lecce, Italy.ORCID 0000-0002-3908-4796
Gianluigi Giannelli1. National Institute of Gastroenterology “Saverio de Bellis”, IRCCS Research Hospital, Castellana Grotte, 70013 Bari, Italy
Giuseppe MaruccioOmnics Research Group, Department of Mathematics and Physics "Ennio De Giorgi", Institute of Nanotechnology CNR-Nanotec and INFN Sezione di Lecce, University of Salento, Via per Monteroni, 73100 Lecce, Italy.ORCID 0000-0001-7669-0253

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a highly lethal cancer, and although a few drugs are available for treatment, therapeutic effectiveness is still unsatisfactory. New drugs are urgently needed for hepatocellular carcinoma (HCC) patients. In this context, reliable preclinical assays are of paramount importance to screen the effectiveness of new drugs and, in particular, measure their effects on HCC cell proliferation. However, cell proliferation measurement is a time-consuming and operator-dependent procedure. The aim of this study was to validate an engineered miniaturized on-chip platform for real-time, non-destructive cell proliferation assays and drug screening. The effectiveness of

Indexed as

Cell ProliferationLab-On-A-Chip DevicesAntineoplastic AgentsCarcinoma, HepatocellularDrug Evaluation, PreclinicalFibroblastsHumansLiver NeoplasmsSorafenibAntineoplastic AgentsSorafenibcell proliferationdrug screeningelectrochemical impedance spectroscopyhepatocellular carcinomalab-on-chipmicrofluidicson-chip assaysSorafenib

Identifiers

PMID34884894
PMCPMC8658471

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.