Evidence map›Paper›PMID 34884889›Full record

ArticleInternational journal of molecular sciences2021

GPR55 Antagonist CID16020046 Protects against Atherosclerosis Development in Mice by Inhibiting Monocyte Adhesion and Mac-1 Expression.

Seung-Jin Lee, Dong-Soon Im

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Targeting the LPI/GPR55 Axis in MAFLD and MASH: Novel Insights, Therapeutic Strategies and Future Directions.Liver international : official journal of the International Association for the Study of the Liver · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Seung-Jin LeeDepartment of Pharmacy, College of Pharmacy, Pusan National University, Busan 46241, Korea.
Dong-Soon ImEast West Pharmaceutical Research Center, Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Korea.ORCID 0000-0001-8054-8946
Kyung Hee University · KRPusan National University · KR

Funding

National Research Foundation of Korea NRF-2020R1A4A1016142, NRF-2019R1A2C1011206, and NRF-2019R1A2C1005523
6 · The paper itself

Abstract

GPR55 recognizes several lipid molecules such as lysophosphatidylinositol. GPR55 expression was reported in human monocytes. However, its role in monocyte adhesion and atherosclerosis development has not been studied. The role of GPR55 in monocyte adhesion and atherosclerosis development was investigated in human THP-1 monocytes and ApoE

Indexed as

AnimalsAtherosclerosisAzabicyclo CompoundsBenzoatesDiet, High-FatGene Expression RegulationHumansHuman Umbilical Vein Endothelial CellsMacrophage-1 AntigenMaleMiceMice, Knockout, ApoEMonocytesProtective AgentsReceptors, CannabinoidSignal Transduction4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acidAzabicyclo CompoundsBenzoatesGPR55 protein, mouseMacrophage-1 AntigenProtective AgentsReceptors, CannabinoidatherosclerosisCID16020046GPR55Mac-1monocyte adhesion

Identifiers

PMID34884889
PMCPMC8658038
OpenAlexW4200438160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.