Evidence map›Paper›PMID 34884869›Full record

ArticleInternational journal of molecular sciences2021

Microglia-Derived Olfactomedin-like 3 Promotes Pro-Tumorigenic Microglial Function and Malignant Features of Glioma Cells.

Ryan G Toedebusch, Christopher A Lucchesi, Eshetu T Debebe, Luke A Wittenburg, Xinbin Chen, Christine M Toedebusch

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Microglia and Brain Macrophages as Drivers of Glioma Progression.International journal of molecular sciences · 2022
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ryan G ToedebuschDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Christopher A LucchesiDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Eshetu T DebebeDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Luke A WittenburgDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Xinbin ChenDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.ORCID 0000-0002-4582-6506
Christine M ToedebuschDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.ORCID 0000-0002-3216-3344
University of California, Davis · US

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9M
UC Davis Paul Calabresi K12 Clinical Oncology Research Career Development ProgramK12CA138464 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BIRKELAND, ANDREW CHARLES, LARA, PRIMO N. · 2011 to 2025
$11.4M
Defining the role of core binding factor protein interactions in osteosarcomaK01OD026526 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WITTENBURG, LUKE A. · 2018 to 2022
$675k
NCI NIH HHS 2K12CA138464-11NCI NIH HHS K12 CA138464NCI NIH HHS P30 CA093373NIH HHS K01 OD026526University of California Comprehensive Cancer Center CANCERCOP2-WT
6 · The paper itself

Abstract

Under the influence of transforming growth factor-beta (TGFβ), glioma-associated microglia produce molecules that promote glioma growth and invasion. Olfactomedin-like 3 (

Indexed as

AnimalsBrain NeoplasmsCell Line, TumorCell MovementChemotaxisGene Expression Regulation, NeoplasticGliomaGlycoproteinsHumansIntercellular Signaling Peptides and ProteinsMiceMice, KnockoutMicrogliaPhagocytosisTransforming Growth Factor betaTumor MicroenvironmentGlycoproteinsIntercellular Signaling Peptides and ProteinsOLFML3 protein, humanOlfml3 protein, mouseTransforming Growth Factor betaglioblastomamicrogliaolfactomedin-like 3TGFβ

Identifiers

PMID34884869
PMCPMC8657851
OpenAlexW3216677794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.