Evidence map›Paper›PMID 34884838›Full record

ArticleInternational journal of molecular sciences2021

Chimeric Investigations into the Diamide Binding Site on the Lepidopteran Ryanodine Receptor.

Ewan Richardson, Bartek J Troczka, Oliver Gutbrod, Ulrich Ebbinghaus-Kintscher, Martin S Williamson, Christopher H George, Ralf Nauen, Thomas G Emyr Davies

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Ewan RichardsonDepartment of Biointeractions and Crop Protection, Rothamsted Research, Harpenden AL5 2JQ, UK.
Bartek J TroczkaDepartment of Biointeractions and Crop Protection, Rothamsted Research, Harpenden AL5 2JQ, UK.
Oliver GutbrodBayer AG, Crop Science Division, R&D, D-40789 Monheim, Germany.
Ulrich Ebbinghaus-KintscherBayer AG, Crop Science Division, R&D, D-40789 Monheim, Germany.
Martin S WilliamsonDepartment of Biointeractions and Crop Protection, Rothamsted Research, Harpenden AL5 2JQ, UK.
Christopher H GeorgeInstitute of Life Sciences, Swansea University Medical School, Swansea SA2 8PP, UK.ORCID 0000-0001-9852-1135
Ralf NauenBayer AG, Crop Science Division, R&D, D-40789 Monheim, Germany.ORCID 0000-0002-7525-8589
Thomas G Emyr DaviesDepartment of Biointeractions and Crop Protection, Rothamsted Research, Harpenden AL5 2JQ, UK.
Bayer (Germany) · DERothamsted Research · GBSwansea University · GBUniversity of Exeter · GB

Funding

Bayer CropScience BB/N504075/1Biotechnology and Biological Sciences Research Council BB/N504075/1
6 · The paper itself

Abstract

Alterations to amino acid residues G4946 and I4790, associated with resistance to diamide insecticides, suggests a location of diamide interaction within the pVSD voltage sensor-like domain of the insect ryanodine receptor (RyR). To further delineate the interaction site(s), targeted alterations were made within the same pVSD region on the diamondback moth (

Indexed as

AnimalsBinding SitesCaffeineCalcium SignalingDiamideHumansInsecticide ResistanceInsecticidesInsect ProteinsMothsMutagenesis, Site-Directedortho-AminobenzoatesRecombinant Fusion ProteinsRyanodine Receptor Calcium Release ChannelCaffeinechlorantranilipoleDiamideInsecticidesInsect Proteinsortho-AminobenzoatesRecombinant Fusion ProteinsRyanodine Receptor Calcium Release ChannelRYR1 protein, humanbinding sitechlorantraniliprolediamide insecticidesflubendiamidelepidopteraPlutella xylostella

Identifiers

PMID34884838
PMCPMC8657592
OpenAlexW3215872965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.