Evidence map›Paper›PMID 34884825›Full record

ArticleInternational journal of molecular sciences2021

Sandra M Fernández-Moya, Janina Ehses, Karl E Bauer, Rico Schieweck, Anob M Chakrabarti, Flora C Y Lee, Christin Illig, Nicholas M Luscombe, Max Harner, Jernej Ule and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Identification of RNA structures and their roles in RNA functions.Nature reviews. Molecular cell biology · 2024
    Review
  6. A positive feedback circuit between RN7SK snRNA and mMolecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Sandra M Fernández-MoyaDepartment for Cell Biology & Anatomy, Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-University, 82152 Planegg-Martinsried, Germany.ORCID 0000-0002-5894-4296
Janina EhsesDepartment for Cell Biology & Anatomy, Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-University, 82152 Planegg-Martinsried, Germany.ORCID 0000-0003-0634-769X
Karl E BauerDepartment for Cell Biology & Anatomy, Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-University, 82152 Planegg-Martinsried, Germany.
Rico SchieweckDepartment for Cell Biology & Anatomy, Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-University, 82152 Planegg-Martinsried, Germany.
Anob M ChakrabartiRNA Network Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Flora C Y LeeRNA Network Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0000-0002-3216-9754
Christin IlligDepartment for Cell Biology & Anatomy, Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-University, 82152 Planegg-Martinsried, Germany.
Nicholas M LuscombeRNA Network Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Max HarnerDepartment for Cell Biology & Anatomy, Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-University, 82152 Planegg-Martinsried, Germany.ORCID 0000-0002-5513-1046
Jernej UleRNA Network Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Michael A KieblerDepartment for Cell Biology & Anatomy, Biomedical Center (BMC), Medical Faculty, Ludwig-Maximilians-University, 82152 Planegg-Martinsried, Germany.ORCID 0000-0002-8850-6297
The Francis Crick Institute · GBOkinawa Institute of Science and Technology Graduate University · JP

Funding

Deutsche Forschungsgemeinschaft FOR2333, SPP1738Wellcome Trust FC001110, 110292/Z/15/Z, 105202/Z/14/Z, 103760/Z/14/, 215593/Z/19/Z
6 · The paper itself

Abstract

RNA-binding proteins (RBPs) act as posttranscriptional regulators controlling the fate of target mRNAs. Unraveling how RNAs are recognized by RBPs and in turn are assembled into neuronal RNA granules is therefore key to understanding the underlying mechanism. While RNA sequence elements have been extensively characterized, the functional impact of RNA secondary structures is only recently being explored. Here, we show that Staufen2 binds complex, long-ranged RNA hairpins in the 3'-untranslated region (UTR) of its targets. These structures are involved in the assembly of Staufen2 into RNA granules. Furthermore, we provide direct evidence that a defined

Indexed as

3' Untranslated RegionsAnimalsCells, CulturedCytoplasmic Ribonucleoprotein GranulesFemaleNeuronsNucleic Acid ConformationRatsRats, Sprague-DawleyRGS ProteinsRNA-Binding ProteinsRNA InterferenceRNA, MessengerRNA, Small Interfering3' Untranslated RegionsRGS4 proteinRGS ProteinsRNA-Binding ProteinsRNA, MessengerRNA, Small InterferingStau2 protein, ratin vivo RNA bindingneuronal RNA granuleRNA-binding proteinRNA localizationRNP assemblyStaufen2

Identifiers

PMID34884825
PMCPMC8657808
OpenAlexW3217746281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.