Evidence map›Paper›PMID 34884824›Full record

ArticleInternational journal of molecular sciences2021

Increased Systemic Antioxidant Power Ameliorates the Aging-Related Reduction in Oocyte Competence in Mice.

Sydney L Lane, Jason C Parks, Jennifer E Russ, Shaihla A Khan, William B Schoolcraft, Ye Yuan, Mandy G Katz-Jaffe

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Apigenin Prevents Ovarian Aging by Regulating CaAntioxidants (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Article
  4. Depletion ofInternational journal of molecular sciences · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sydney L LaneColorado Center for Reproductive Medicine, Lone Tree, CO 80124, USA.
Jason C ParksColorado Center for Reproductive Medicine, Lone Tree, CO 80124, USA.
Jennifer E RussColorado Center for Reproductive Medicine, Lone Tree, CO 80124, USA.
Shaihla A KhanColorado Center for Reproductive Medicine, Lone Tree, CO 80124, USA.
William B SchoolcraftColorado Center for Reproductive Medicine, Lone Tree, CO 80124, USA.
Ye YuanColorado Center for Reproductive Medicine, Lone Tree, CO 80124, USA.
Mandy G Katz-JaffeColorado Center for Reproductive Medicine, Lone Tree, CO 80124, USA.ORCID 0000-0002-6439-3160
Colorado Center for Reproductive Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian aging is associated with elevated oxidative stress and diminished oocyte developmental competence. We aimed to determine the impact of systemic antioxidant treatment in aged mice. Female outbred CF-1 mice were aged for 9 months prior to an 8-week 45 mg

Indexed as

AgingAnimalsAntioxidantsBlastocystEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressEuterpeFemaleMiceMitochondriaOocytesOxidative StressPlant ExtractsProtein Disulfide-IsomerasesSuperoxide Dismutase-1AntioxidantsEndoplasmic Reticulum Chaperone BiPHspa5 protein, mousePdia4 protein, mousePlant ExtractsProtein Disulfide-IsomerasesSuperoxide Dismutase-1agingantioxidantsinfertilityoocyte competenceoxidative stress

Identifiers

PMID34884824
PMCPMC8657807
OpenAlexW3217238441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.